Cargando…

Sec61p Is Required for ERAD-L: GENETIC DISSECTION OF THE TRANSLOCATION AND ERAD-L FUNCTIONS OF Sec61P USING NOVEL DERIVATIVES OF CPY

Misfolded proteins in the endoplasmic reticulum (ER) are exported to the cytosol for degradation by the proteasome in a process known as ER-associated degradation (ERAD). CPY* is a well characterized ERAD substrate whose degradation is dependent upon the Hrd1 complex. However, although the functions...

Descripción completa

Detalles Bibliográficos
Autores principales:	Willer, Martin, Forte, Gabriella M. A., Stirling, Colin J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590686/ https://www.ncbi.nlm.nih.gov/pubmed/18819915 http://dx.doi.org/10.1074/jbc.M803054200

Ejemplares similares

Structural and Functional Dissection of the Heterocyclic Peptide Cytotoxin Streptolysin S
por: Mitchell, Douglas A., et al.
Publicado: (2009)

Role of pICLn in Methylation of Sm Proteins by PRMT5
por: Pesiridis, G. Scott, et al.
Publicado: (2009)

Structure and Function of the PLAA/Ufd3-p97/Cdc48 Complex
por: Qiu, Liyan, et al.
Publicado: (2010)

Regulation of Postsynaptic RapGAP SPAR by Polo-like Kinase 2 and the SCF(β-TRCP) Ubiquitin Ligase in Hippocampal Neurons
por: Ang, Xiaolu L., et al.
Publicado: (2008)

Dual Specificity Phosphatases 18 and 21 Target to Opposing Sides of the Mitochondrial Inner Membrane
por: Rardin, Matthew J., et al.
Publicado: (2008)

Systematic Structure-Activity Analysis of Microcin J25
por: Pavlova, Olga, et al.
Publicado: (2008)

The Motor Complex of Plasmodium falciparum: PHOSPHORYLATION BY A CALCIUM-DEPENDENT PROTEIN KINASE
por: Green, Judith L., et al.
Publicado: (2008)

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival
por: Liu, Liping, et al.
Publicado: (2008)

S-Nitrosylated Human Serum Albumin-mediated Cytoprotective Activity Is Enhanced by Fatty Acid Binding
por: Ishima, Yu, et al.
Publicado: (2008)

Ricin B Chain Targeted to the Endoplasmic Reticulum of Tobacco Protoplasts Is Degraded by a CDC48- and Vacuole-independent Mechanism
por: Chamberlain, Kerry L., et al.
Publicado: (2008)

The HLA-DRα Chain Is Modified by Polyubiquitination
por: Lapaque, Nicolas, et al.
Publicado: (2009)

Regulation of C-type Lectin Antimicrobial Activity by a Flexible N-terminal Prosegment
por: Mukherjee, Sohini, et al.
Publicado: (2009)

Multiple Anaphase-promoting Complex/Cyclosome Degrons Mediate the Degradation of Human Sgo1
por: Karamysheva, Zemfira, et al.
Publicado: (2009)

Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein
por: Taylor, David R., et al.
Publicado: (2009)

Splicing of the Mycobacteriophage Bethlehem DnaB Intein: IDENTIFICATION OF A NEW MECHANISTIC CLASS OF INTEINS THAT CONTAIN AN OBLIGATE BLOCK F NUCLEOPHILE
por: Tori, Kazuo, et al.
Publicado: (2010)

Cordycepin Inhibits Protein Synthesis and Cell Adhesion through Effects on Signal Transduction
por: Wong, Ying Ying, et al.
Publicado: (2010)

Substrate Specificity of the Oxidoreductase ERp57 Is Determined Primarily by Its Interaction with Calnexin and Calreticulin
por: Jessop, Catherine E., et al.
Publicado: (2009)

The Acidic Tail of the Cdc34 Ubiquitin-conjugating Enzyme Functions in Both Binding to and Catalysis with Ubiquitin Ligase SCF(Cdc4)
por: Kleiger, Gary, et al.
Publicado: (2009)

Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)
por: Lambert, Daniel W., et al.
Publicado: (2005)

The N-terminus of Sec61p plays key roles in ER protein import and ERAD
por: Elia, Francesco, et al.
Publicado: (2019)

Role of the Cytoplasmic Segments of Sec61α in the Ribosome-Binding and Translocation-Promoting Activities of the Sec61 Complex
por: Raden, David, et al.
Publicado: (2000)

Ubiquitination of the N-terminal Region of Caveolin-1 Regulates Endosomal Sorting by the VCP/p97 AAA-ATPase
por: Kirchner, Philipp, et al.
Publicado: (2013)

Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates
por: Masuda, Yuji, et al.
Publicado: (2019)

Proteasome 19S RP Binding to the Sec61 Channel Plays a Key Role in ERAD
por: Kaiser, Marie-Luise, et al.
Publicado: (2015)

Loopy Sec61 mutants
por: LeBrasseur, Nicole
Publicado: (2005)

Sec61β, a subunit of the Sec61 protein translocation channel at the Endoplasmic Reticulum, is involved in the transport of Gurken to the plasma membrane.
por: Kelkar, Anshuman, et al.
Publicado: (2009)

Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex
por: Sicking, Mark, et al.
Publicado: (2021)

Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation
por: Cheng, Zhiliang, et al.
Publicado: (2005)

ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7
por: Tretter, Thomas, et al.
Publicado: (2013)

Yeast 18 S rRNA Is Directly Involved in the Ribosomal Response to Stringent AUG Selection during Translation Initiation
por: Nemoto, Naoki, et al.
Publicado: (2010)

Biochemical and Structural Studies of a HECT-like Ubiquitin Ligase from Escherichia coli O157:H7
por: Lin, David Yin-wei, et al.
Publicado: (2011)

Self-assembly of Severe Acute Respiratory Syndrome Coronavirus Membrane Protein
por: Tseng, Ying-Tzu, et al.
Publicado: (2010)

Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets
por: Hartman, Isamu Z., et al.
Publicado: (2010)

Repair of Isoaspartate Formation Modulates the Interaction of Deamidated 4E-BP2 with mTORC1 in Brain
por: Bidinosti, Michael, et al.
Publicado: (2010)

Further in Vitro Exploration Fails to Support the Allosteric Three-site Model
por: Petropoulos, Alexandros D., et al.
Publicado: (2012)

Identification of Intersubunit Domain Interactions within Eukaryotic Initiation Factor (eIF) 2B, the Nucleotide Exchange Factor for Translation Initiation
por: Reid, Peter J., et al.
Publicado: (2012)

Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase
por: Jo, Youngah, et al.
Publicado: (2011)

Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System
por: Chou, Tsui-Fen, et al.
Publicado: (2011)

Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis
por: Frank, Christopher L., et al.
Publicado: (2010)

Functional Characterization of the Role of the N-terminal Domain of the c/Nip1 Subunit of Eukaryotic Initiation Factor 3 (eIF3) in AUG Recognition
por: Karásková, Martina, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_e8u7lm2mg281os63akdhtgmggh