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PcG Proteins, DNA Methylation, and Gene Repression by Chromatin Looping

Many DNA hypermethylated and epigenetically silenced genes in adult cancers are Polycomb group (PcG) marked in embryonic stem (ES) cells. We show that a large region upstream (∼30 kb) of and extending ∼60 kb around one such gene, GATA-4, is organized—in Tera-2 undifferentiated embryonic carcinoma (E...

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Detalles Bibliográficos
Autores principales:	Tiwari, Vijay K, McGarvey, Kelly M, Licchesi, Julien D.F, Ohm, Joyce E, Herman, James G, Schübeler, Dirk, Baylin, Stephen B
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592355/ https://www.ncbi.nlm.nih.gov/pubmed/19053175 http://dx.doi.org/10.1371/journal.pbio.0060306

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