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Developments in the scientific understanding of lupus

Systemic lupus erythematosus is a systemic autoimmune disease characterized by the production of antinuclear antibodies (ANAs). Recent research into human and murine lupus suggests that disease susceptibility results from genetic polymorphisms regulating immune responses as well as impairing the cle...

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Detalles Bibliográficos
Autores principales: Ardoin, Stacy P, Pisetsky, David S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592776/
https://www.ncbi.nlm.nih.gov/pubmed/18947369
http://dx.doi.org/10.1186/ar2488
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author Ardoin, Stacy P
Pisetsky, David S
author_facet Ardoin, Stacy P
Pisetsky, David S
author_sort Ardoin, Stacy P
collection PubMed
description Systemic lupus erythematosus is a systemic autoimmune disease characterized by the production of antinuclear antibodies (ANAs). Recent research into human and murine lupus suggests that disease susceptibility results from genetic polymorphisms regulating immune responses as well as impairing the clearance of apoptotic cells. Because the products of dead cells, including nucleic acids, have immunologic activity, this situation can promote antigen-driven ANA responses. Furthermore, immune complexes of ANAs can drive the production of proinflammatory cytokines, inducing the 'interferon signature', and intensifying disease. Together, these findings point to new genetic and immunologic markers of disease as well as targets for new therapies.
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spelling pubmed-25927762008-12-03 Developments in the scientific understanding of lupus Ardoin, Stacy P Pisetsky, David S Arthritis Res Ther Review Systemic lupus erythematosus is a systemic autoimmune disease characterized by the production of antinuclear antibodies (ANAs). Recent research into human and murine lupus suggests that disease susceptibility results from genetic polymorphisms regulating immune responses as well as impairing the clearance of apoptotic cells. Because the products of dead cells, including nucleic acids, have immunologic activity, this situation can promote antigen-driven ANA responses. Furthermore, immune complexes of ANAs can drive the production of proinflammatory cytokines, inducing the 'interferon signature', and intensifying disease. Together, these findings point to new genetic and immunologic markers of disease as well as targets for new therapies. BioMed Central 2008 2008-10-10 /pmc/articles/PMC2592776/ /pubmed/18947369 http://dx.doi.org/10.1186/ar2488 Text en Copyright © 2008 BioMed Central Ltd
spellingShingle Review
Ardoin, Stacy P
Pisetsky, David S
Developments in the scientific understanding of lupus
title Developments in the scientific understanding of lupus
title_full Developments in the scientific understanding of lupus
title_fullStr Developments in the scientific understanding of lupus
title_full_unstemmed Developments in the scientific understanding of lupus
title_short Developments in the scientific understanding of lupus
title_sort developments in the scientific understanding of lupus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592776/
https://www.ncbi.nlm.nih.gov/pubmed/18947369
http://dx.doi.org/10.1186/ar2488
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