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Are biologics more effective than classical disease-modifying antirheumatic drugs?

Major achievements have been reached in the treatment of rheumatoid arthritis during past decades due to the recognition of methotrexate as an anchor drug for treatment of rheumatoid arthritis, due to the notion of a treatment window of opportunity in patients with recent-onset rheumatoid arthritis...

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Detalles Bibliográficos
Autores principales: Nurmohamed, Michael T, Dijkmans, Ben AC
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592779/
https://www.ncbi.nlm.nih.gov/pubmed/18828888
http://dx.doi.org/10.1186/ar2491
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author Nurmohamed, Michael T
Dijkmans, Ben AC
author_facet Nurmohamed, Michael T
Dijkmans, Ben AC
author_sort Nurmohamed, Michael T
collection PubMed
description Major achievements have been reached in the treatment of rheumatoid arthritis during past decades due to the recognition of methotrexate as an anchor drug for treatment of rheumatoid arthritis, due to the notion of a treatment window of opportunity in patients with recent-onset rheumatoid arthritis necessitating early aggressive therapy, due to the development of biologics and due to remission as a treatment target. Most biologics have a much faster onset of action than synthetic disease-modifying anti-rheumatic drugs, but presently there is no convincing evidence that biologic drugs have a superior clinical efficacy in comparison with the synthetic drugs. Biologics are, however, accompanied by less radiological deterioration.
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spelling pubmed-25927792008-12-03 Are biologics more effective than classical disease-modifying antirheumatic drugs? Nurmohamed, Michael T Dijkmans, Ben AC Arthritis Res Ther Commentary Major achievements have been reached in the treatment of rheumatoid arthritis during past decades due to the recognition of methotrexate as an anchor drug for treatment of rheumatoid arthritis, due to the notion of a treatment window of opportunity in patients with recent-onset rheumatoid arthritis necessitating early aggressive therapy, due to the development of biologics and due to remission as a treatment target. Most biologics have a much faster onset of action than synthetic disease-modifying anti-rheumatic drugs, but presently there is no convincing evidence that biologic drugs have a superior clinical efficacy in comparison with the synthetic drugs. Biologics are, however, accompanied by less radiological deterioration. BioMed Central 2008 2008-09-19 /pmc/articles/PMC2592779/ /pubmed/18828888 http://dx.doi.org/10.1186/ar2491 Text en Copyright © 2008 BioMed Central Ltd
spellingShingle Commentary
Nurmohamed, Michael T
Dijkmans, Ben AC
Are biologics more effective than classical disease-modifying antirheumatic drugs?
title Are biologics more effective than classical disease-modifying antirheumatic drugs?
title_full Are biologics more effective than classical disease-modifying antirheumatic drugs?
title_fullStr Are biologics more effective than classical disease-modifying antirheumatic drugs?
title_full_unstemmed Are biologics more effective than classical disease-modifying antirheumatic drugs?
title_short Are biologics more effective than classical disease-modifying antirheumatic drugs?
title_sort are biologics more effective than classical disease-modifying antirheumatic drugs?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592779/
https://www.ncbi.nlm.nih.gov/pubmed/18828888
http://dx.doi.org/10.1186/ar2491
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