Cargando…
Are biologics more effective than classical disease-modifying antirheumatic drugs?
Major achievements have been reached in the treatment of rheumatoid arthritis during past decades due to the recognition of methotrexate as an anchor drug for treatment of rheumatoid arthritis, due to the notion of a treatment window of opportunity in patients with recent-onset rheumatoid arthritis...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592779/ https://www.ncbi.nlm.nih.gov/pubmed/18828888 http://dx.doi.org/10.1186/ar2491 |
_version_ | 1782161579109777408 |
---|---|
author | Nurmohamed, Michael T Dijkmans, Ben AC |
author_facet | Nurmohamed, Michael T Dijkmans, Ben AC |
author_sort | Nurmohamed, Michael T |
collection | PubMed |
description | Major achievements have been reached in the treatment of rheumatoid arthritis during past decades due to the recognition of methotrexate as an anchor drug for treatment of rheumatoid arthritis, due to the notion of a treatment window of opportunity in patients with recent-onset rheumatoid arthritis necessitating early aggressive therapy, due to the development of biologics and due to remission as a treatment target. Most biologics have a much faster onset of action than synthetic disease-modifying anti-rheumatic drugs, but presently there is no convincing evidence that biologic drugs have a superior clinical efficacy in comparison with the synthetic drugs. Biologics are, however, accompanied by less radiological deterioration. |
format | Text |
id | pubmed-2592779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25927792008-12-03 Are biologics more effective than classical disease-modifying antirheumatic drugs? Nurmohamed, Michael T Dijkmans, Ben AC Arthritis Res Ther Commentary Major achievements have been reached in the treatment of rheumatoid arthritis during past decades due to the recognition of methotrexate as an anchor drug for treatment of rheumatoid arthritis, due to the notion of a treatment window of opportunity in patients with recent-onset rheumatoid arthritis necessitating early aggressive therapy, due to the development of biologics and due to remission as a treatment target. Most biologics have a much faster onset of action than synthetic disease-modifying anti-rheumatic drugs, but presently there is no convincing evidence that biologic drugs have a superior clinical efficacy in comparison with the synthetic drugs. Biologics are, however, accompanied by less radiological deterioration. BioMed Central 2008 2008-09-19 /pmc/articles/PMC2592779/ /pubmed/18828888 http://dx.doi.org/10.1186/ar2491 Text en Copyright © 2008 BioMed Central Ltd |
spellingShingle | Commentary Nurmohamed, Michael T Dijkmans, Ben AC Are biologics more effective than classical disease-modifying antirheumatic drugs? |
title | Are biologics more effective than classical disease-modifying antirheumatic drugs? |
title_full | Are biologics more effective than classical disease-modifying antirheumatic drugs? |
title_fullStr | Are biologics more effective than classical disease-modifying antirheumatic drugs? |
title_full_unstemmed | Are biologics more effective than classical disease-modifying antirheumatic drugs? |
title_short | Are biologics more effective than classical disease-modifying antirheumatic drugs? |
title_sort | are biologics more effective than classical disease-modifying antirheumatic drugs? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592779/ https://www.ncbi.nlm.nih.gov/pubmed/18828888 http://dx.doi.org/10.1186/ar2491 |
work_keys_str_mv | AT nurmohamedmichaelt arebiologicsmoreeffectivethanclassicaldiseasemodifyingantirheumaticdrugs AT dijkmansbenac arebiologicsmoreeffectivethanclassicaldiseasemodifyingantirheumaticdrugs |