The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching

The metamorphic Mad2 protein acts as a molecular switch in the checkpoint mechanism that monitors proper chromosome attachment to spindle microtubules during cell division. The remarkably slow spontaneous rate of Mad2 switching between its checkpoint inactive and active forms is catalyzed onto a phy...

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Detalles Bibliográficos
Autores principales: Skinner, John J., Wood, Stacey, Shorter, James, Englander, S. Walter, Black, Ben E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592820/
https://www.ncbi.nlm.nih.gov/pubmed/19029339
http://dx.doi.org/10.1083/jcb.200808122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592820/
https://www.ncbi.nlm.nih.gov/pubmed/19029339
http://dx.doi.org/10.1083/jcb.200808122

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