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Drug use in children: cohort study in three European countries

Objective To provide an overview of drug use in children in three European countries. Design Retrospective cohort study, 2000-5. Setting Primary care research databases in the Netherlands (IPCI), United Kingdom (IMS-DA), and Italy (Pedianet). Participants 675 868 children aged up to 14 (Italy) or 18...

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Autores principales: Sturkenboom, Miriam C J M, Verhamme, Katia M C, Nicolosi, Alfredo, Murray, Macey L, Neubert, Antje, Caudri, Daan, Picelli, Gino, Sen, Elif Fatma, Giaquinto, Carlo, Cantarutti, Luigi, Baiardi, Paola, Felisi, Maria-Grazia, Ceci, Adriana, Wong, Ian C K
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593449/
https://www.ncbi.nlm.nih.gov/pubmed/19029175
http://dx.doi.org/10.1136/bmj.a2245
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author Sturkenboom, Miriam C J M
Verhamme, Katia M C
Nicolosi, Alfredo
Murray, Macey L
Neubert, Antje
Caudri, Daan
Picelli, Gino
Sen, Elif Fatma
Giaquinto, Carlo
Cantarutti, Luigi
Baiardi, Paola
Felisi, Maria-Grazia
Ceci, Adriana
Wong, Ian C K
author_facet Sturkenboom, Miriam C J M
Verhamme, Katia M C
Nicolosi, Alfredo
Murray, Macey L
Neubert, Antje
Caudri, Daan
Picelli, Gino
Sen, Elif Fatma
Giaquinto, Carlo
Cantarutti, Luigi
Baiardi, Paola
Felisi, Maria-Grazia
Ceci, Adriana
Wong, Ian C K
author_sort Sturkenboom, Miriam C J M
collection PubMed
description Objective To provide an overview of drug use in children in three European countries. Design Retrospective cohort study, 2000-5. Setting Primary care research databases in the Netherlands (IPCI), United Kingdom (IMS-DA), and Italy (Pedianet). Participants 675 868 children aged up to 14 (Italy) or 18 (UK and Netherlands). Main outcome measure Prevalence of use per year calculated by drug class (anatomical and therapeutic). Prevalence of “recurrent/chronic” use (three or more prescriptions a year) and “non-recurrent” or “acute” use (less than three prescriptions a year) within each therapeutic class. Descriptions of the top five most commonly used drugs evaluated for off label status within each anatomical class. Results Three levels of drug use could be distinguished in the study population: high (>10/100 children per year), moderate (1-10/100 children per year), and low (<1/100 children per year). For all age categories, anti-infective, dermatological, and respiratory drugs were in the high use group, whereas cardiovascular and antineoplastic drugs were always in the low use group. Emollients, topical steroids, and asthma drugs had the highest prevalence of recurrent use, but relative use of low prevalence drugs was more often recurrent than acute. In the top five highest prevalence drugs topical inhaled and systemic steroids, oral contraceptives, and topical or systemic antifungal drugs were most commonly used off label. Conclusion This overview of outpatient paediatric prescription patterns in a large European population could provide information to prioritise paediatric therapeutic research needs.
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spelling pubmed-25934492008-12-04 Drug use in children: cohort study in three European countries Sturkenboom, Miriam C J M Verhamme, Katia M C Nicolosi, Alfredo Murray, Macey L Neubert, Antje Caudri, Daan Picelli, Gino Sen, Elif Fatma Giaquinto, Carlo Cantarutti, Luigi Baiardi, Paola Felisi, Maria-Grazia Ceci, Adriana Wong, Ian C K BMJ Research Objective To provide an overview of drug use in children in three European countries. Design Retrospective cohort study, 2000-5. Setting Primary care research databases in the Netherlands (IPCI), United Kingdom (IMS-DA), and Italy (Pedianet). Participants 675 868 children aged up to 14 (Italy) or 18 (UK and Netherlands). Main outcome measure Prevalence of use per year calculated by drug class (anatomical and therapeutic). Prevalence of “recurrent/chronic” use (three or more prescriptions a year) and “non-recurrent” or “acute” use (less than three prescriptions a year) within each therapeutic class. Descriptions of the top five most commonly used drugs evaluated for off label status within each anatomical class. Results Three levels of drug use could be distinguished in the study population: high (>10/100 children per year), moderate (1-10/100 children per year), and low (<1/100 children per year). For all age categories, anti-infective, dermatological, and respiratory drugs were in the high use group, whereas cardiovascular and antineoplastic drugs were always in the low use group. Emollients, topical steroids, and asthma drugs had the highest prevalence of recurrent use, but relative use of low prevalence drugs was more often recurrent than acute. In the top five highest prevalence drugs topical inhaled and systemic steroids, oral contraceptives, and topical or systemic antifungal drugs were most commonly used off label. Conclusion This overview of outpatient paediatric prescription patterns in a large European population could provide information to prioritise paediatric therapeutic research needs. BMJ Publishing Group Ltd. 2008-11-24 /pmc/articles/PMC2593449/ /pubmed/19029175 http://dx.doi.org/10.1136/bmj.a2245 Text en © Sturkenboom et al 2008 http://creativecommons.org/licenses/by-nc/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Sturkenboom, Miriam C J M
Verhamme, Katia M C
Nicolosi, Alfredo
Murray, Macey L
Neubert, Antje
Caudri, Daan
Picelli, Gino
Sen, Elif Fatma
Giaquinto, Carlo
Cantarutti, Luigi
Baiardi, Paola
Felisi, Maria-Grazia
Ceci, Adriana
Wong, Ian C K
Drug use in children: cohort study in three European countries
title Drug use in children: cohort study in three European countries
title_full Drug use in children: cohort study in three European countries
title_fullStr Drug use in children: cohort study in three European countries
title_full_unstemmed Drug use in children: cohort study in three European countries
title_short Drug use in children: cohort study in three European countries
title_sort drug use in children: cohort study in three european countries
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593449/
https://www.ncbi.nlm.nih.gov/pubmed/19029175
http://dx.doi.org/10.1136/bmj.a2245
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