Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma

Infantile hemangiomas are localized and rapidly growing regions of disorganized angiogenesis. We demonstrate that expression of VEGFR1 in hemangioma endothelial cells (hemEC) and tissue is only 10−20% of that in controls. Low VEGFR1 levels result in VEGF-dependent activation of VEGFR2 and downstream...

Descripción completa

Detalles Bibliográficos
Autores principales: Jinnin, Masatoshi, Medici, Damian, Park, Lucy, Limaye, Nisha, Liu, Yanqiu, Boscolo, Elisa, Bischoff, Joyce, Vikkula, Miikka, Boye, Eileen, Olsen, Bjorn R.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593632/
https://www.ncbi.nlm.nih.gov/pubmed/18931684
http://dx.doi.org/10.1038/nm.1877

Ejemplares similares

Ejemplares similares