Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp.

[Image: see text] Three new sterol sulfates, spheciosterol sulfates A−C (1−3), and the known sterol sulfate topsentiasterol sulfate E (4) have been isolated from the sponge Spheciospongia sp., collected in the Philippines. Structures were assigned on the basis of extensive 1D and 2D NMR studies as w...

Descripción completa

Detalles Bibliográficos
Autores principales: Whitson, Emily L., Bugni, Tim S., Chockalingam, Priya S., Concepcion, Gisela P., Harper, Mary Kay, He, Min, Hooper, John N. A., Mangalindan, Gina C., Ritacco, Frank, Ireland, Chris M.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593898/
https://www.ncbi.nlm.nih.gov/pubmed/18558742
http://dx.doi.org/10.1021/np8001628
Descripción
Sumario:[Image: see text] Three new sterol sulfates, spheciosterol sulfates A−C (1−3), and the known sterol sulfate topsentiasterol sulfate E (4) have been isolated from the sponge Spheciospongia sp., collected in the Philippines. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1−4 inhibited PKCζ with IC(50) values of 1.59, 0.53, 0.11, and 1.21 μM, respectively. In a cell-based assay, 1−4 also inhibited NF-κB activation with EC(50) values of 12−64 μM.

Ejemplares similares