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Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp.
[Image: see text] Three new sterol sulfates, spheciosterol sulfates A−C (1−3), and the known sterol sulfate topsentiasterol sulfate E (4) have been isolated from the sponge Spheciospongia sp., collected in the Philippines. Structures were assigned on the basis of extensive 1D and 2D NMR studies as w...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society and American Society of Pharmacognosy
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593898/ https://www.ncbi.nlm.nih.gov/pubmed/18558742 http://dx.doi.org/10.1021/np8001628 |
| _version_ | 1782161624569741312 |
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| author | Whitson, Emily L. Bugni, Tim S. Chockalingam, Priya S. Concepcion, Gisela P. Harper, Mary Kay He, Min Hooper, John N. A. Mangalindan, Gina C. Ritacco, Frank Ireland, Chris M. |
| author_facet | Whitson, Emily L. Bugni, Tim S. Chockalingam, Priya S. Concepcion, Gisela P. Harper, Mary Kay He, Min Hooper, John N. A. Mangalindan, Gina C. Ritacco, Frank Ireland, Chris M. |
| author_sort | Whitson, Emily L. |
| collection | PubMed |
| description | [Image: see text] Three new sterol sulfates, spheciosterol sulfates A−C (1−3), and the known sterol sulfate topsentiasterol sulfate E (4) have been isolated from the sponge Spheciospongia sp., collected in the Philippines. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1−4 inhibited PKCζ with IC(50) values of 1.59, 0.53, 0.11, and 1.21 μM, respectively. In a cell-based assay, 1−4 also inhibited NF-κB activation with EC(50) values of 12−64 μM. |
| format | Text |
| id | pubmed-2593898 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2008 |
| publisher | American Chemical Society and American Society of Pharmacognosy |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-25938982009-03-20 Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp. Whitson, Emily L. Bugni, Tim S. Chockalingam, Priya S. Concepcion, Gisela P. Harper, Mary Kay He, Min Hooper, John N. A. Mangalindan, Gina C. Ritacco, Frank Ireland, Chris M. J Nat Prod [Image: see text] Three new sterol sulfates, spheciosterol sulfates A−C (1−3), and the known sterol sulfate topsentiasterol sulfate E (4) have been isolated from the sponge Spheciospongia sp., collected in the Philippines. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1−4 inhibited PKCζ with IC(50) values of 1.59, 0.53, 0.11, and 1.21 μM, respectively. In a cell-based assay, 1−4 also inhibited NF-κB activation with EC(50) values of 12−64 μM. American Chemical Society and American Society of Pharmacognosy 2008-06-18 2008-07-25 /pmc/articles/PMC2593898/ /pubmed/18558742 http://dx.doi.org/10.1021/np8001628 Text en Copyright © 2008 American Chemical Society and American Society of Pharmacognosy http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org. 40.75 |
| spellingShingle | Whitson, Emily L. Bugni, Tim S. Chockalingam, Priya S. Concepcion, Gisela P. Harper, Mary Kay He, Min Hooper, John N. A. Mangalindan, Gina C. Ritacco, Frank Ireland, Chris M. Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp. |
| title | Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp. |
| title_full | Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp. |
| title_fullStr | Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp. |
| title_full_unstemmed | Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp. |
| title_short | Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp. |
| title_sort | spheciosterol sulfates, pkcζ inhibitors from a philippine sponge spheciospongia sp. |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593898/ https://www.ncbi.nlm.nih.gov/pubmed/18558742 http://dx.doi.org/10.1021/np8001628 |
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