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Hepatitis A
Hepatitis A is a disease of worldwide distribution which occurs in endemic and epidemic form and is transmitted primarily by person-to-person contact through the fecal-oral route. Common source epidemics due to contamination of food are relatively common, and water-borne epidemics have been describe...
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Formato: | Texto |
Lenguaje: | English |
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1976
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595349/ https://www.ncbi.nlm.nih.gov/pubmed/183390 |
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author | Maynard, James E. |
author_facet | Maynard, James E. |
author_sort | Maynard, James E. |
collection | PubMed |
description | Hepatitis A is a disease of worldwide distribution which occurs in endemic and epidemic form and is transmitted primarily by person-to-person contact through the fecal-oral route. Common source epidemics due to contamination of food are relatively common, and water-borne epidemics have been described less frequently. The presumed etiologic agent of hepatitis A has now been visualized by immune electron microscopic (IEM) techniques in early acute-illness-phase stools of humans with hepatitis A as well as in chimpanzees experimentally infected with material known to contain hepatitis A virus. In addition, several new serologic tests for the detection of antibody against hepatitis A virus have been described. These include complement fixation and immune adherence techniques. Current data suggest that hepatitis A is caused by a single viral agent lacking the morphologic heterogeneity of hepatitis B viral components and that there may be relative antigenic homogeneity between strains of virus recovered from various parts of the world. Serologic studies to date also indicate that hepatitis A virus is not a major contributing cause in post-transfusion hepatitis. |
format | Text |
id | pubmed-2595349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1976 |
record_format | MEDLINE/PubMed |
spelling | pubmed-25953492008-12-05 Hepatitis A Maynard, James E. Yale J Biol Med Articles Hepatitis A is a disease of worldwide distribution which occurs in endemic and epidemic form and is transmitted primarily by person-to-person contact through the fecal-oral route. Common source epidemics due to contamination of food are relatively common, and water-borne epidemics have been described less frequently. The presumed etiologic agent of hepatitis A has now been visualized by immune electron microscopic (IEM) techniques in early acute-illness-phase stools of humans with hepatitis A as well as in chimpanzees experimentally infected with material known to contain hepatitis A virus. In addition, several new serologic tests for the detection of antibody against hepatitis A virus have been described. These include complement fixation and immune adherence techniques. Current data suggest that hepatitis A is caused by a single viral agent lacking the morphologic heterogeneity of hepatitis B viral components and that there may be relative antigenic homogeneity between strains of virus recovered from various parts of the world. Serologic studies to date also indicate that hepatitis A virus is not a major contributing cause in post-transfusion hepatitis. 1976-07 /pmc/articles/PMC2595349/ /pubmed/183390 Text en |
spellingShingle | Articles Maynard, James E. Hepatitis A |
title | Hepatitis A |
title_full | Hepatitis A |
title_fullStr | Hepatitis A |
title_full_unstemmed | Hepatitis A |
title_short | Hepatitis A |
title_sort | hepatitis a |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595349/ https://www.ncbi.nlm.nih.gov/pubmed/183390 |
work_keys_str_mv | AT maynardjamese hepatitisa |