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The etiology of chronic active hepatitis in Korea.

In a study of apparently normal, healthy Korean Army recruits performed in 1962, we found that 42 of 1,906 screened subjects had elevations of their serum glutamic pyruvate transaminase. Liver biopsies were obtained from 32 of these subjects and 9 of these had a "novel" antigen present, wh...

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Detalles Bibliográficos
Autores principales: Prince, A. M., Gershon, R. K.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1979
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595445/
https://www.ncbi.nlm.nih.gov/pubmed/377825
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author Prince, A. M.
Gershon, R. K.
author_facet Prince, A. M.
Gershon, R. K.
author_sort Prince, A. M.
collection PubMed
description In a study of apparently normal, healthy Korean Army recruits performed in 1962, we found that 42 of 1,906 screened subjects had elevations of their serum glutamic pyruvate transaminase. Liver biopsies were obtained from 32 of these subjects and 9 of these had a "novel" antigen present, which reacted specifically with a convalescent serum from a case of serum hepatitis. We have recently tested frozen serum obtained from 8/9 of these cases and found that all 8 had HBsAg in their serum which, in some cases, persisted for at least three months. We reviewed the histological specimens from the original 32 cases using newly defined criteria: 18 were diagnosed as chronic active hepatitis and the 8 HbsAg positive cases with the "novel" antigen were in this group. In four of these cases the lesion appeared to progress to cirrhosis during a 3--4 month follow-up period. Since none of the cases had a prior history of hepatitis and no symptoms developed during the follow-up period, our findings emphasize the significance of chronic hepatitis B virus carrier state in the etiology of cryptogenic cirrhosis.
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spelling pubmed-25954452008-12-05 The etiology of chronic active hepatitis in Korea. Prince, A. M. Gershon, R. K. Yale J Biol Med Research Article In a study of apparently normal, healthy Korean Army recruits performed in 1962, we found that 42 of 1,906 screened subjects had elevations of their serum glutamic pyruvate transaminase. Liver biopsies were obtained from 32 of these subjects and 9 of these had a "novel" antigen present, which reacted specifically with a convalescent serum from a case of serum hepatitis. We have recently tested frozen serum obtained from 8/9 of these cases and found that all 8 had HBsAg in their serum which, in some cases, persisted for at least three months. We reviewed the histological specimens from the original 32 cases using newly defined criteria: 18 were diagnosed as chronic active hepatitis and the 8 HbsAg positive cases with the "novel" antigen were in this group. In four of these cases the lesion appeared to progress to cirrhosis during a 3--4 month follow-up period. Since none of the cases had a prior history of hepatitis and no symptoms developed during the follow-up period, our findings emphasize the significance of chronic hepatitis B virus carrier state in the etiology of cryptogenic cirrhosis. Yale Journal of Biology and Medicine 1979 /pmc/articles/PMC2595445/ /pubmed/377825 Text en
spellingShingle Research Article
Prince, A. M.
Gershon, R. K.
The etiology of chronic active hepatitis in Korea.
title The etiology of chronic active hepatitis in Korea.
title_full The etiology of chronic active hepatitis in Korea.
title_fullStr The etiology of chronic active hepatitis in Korea.
title_full_unstemmed The etiology of chronic active hepatitis in Korea.
title_short The etiology of chronic active hepatitis in Korea.
title_sort etiology of chronic active hepatitis in korea.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595445/
https://www.ncbi.nlm.nih.gov/pubmed/377825
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