Phenobarbital Increases Spontaneous Transmitter Release at the Frog Neuromuscular Junction

Phenobarbital (1-2 × 10(-4)M) markedly increases the frequency of miniature end-plate potentials at the neuromuscular synapse of the frog. This effect was seen in calcium free media containing EGTA. The drug probably acts presynaptically at an intracellular locus to increase the presynaptic free cal...

Descripción completa

Detalles Bibliográficos
Autores principales: Pincus, Jonathan H., Insler, Nancy F.
Formato: Texto
Lenguaje:English
Publicado: 1978
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595670/
https://www.ncbi.nlm.nih.gov/pubmed/28609
_version_ 1782161737500327936
author Pincus, Jonathan H.
Insler, Nancy F.
author_facet Pincus, Jonathan H.
Insler, Nancy F.
author_sort Pincus, Jonathan H.
collection PubMed
description Phenobarbital (1-2 × 10(-4)M) markedly increases the frequency of miniature end-plate potentials at the neuromuscular synapse of the frog. This effect was seen in calcium free media containing EGTA. The drug probably acts presynaptically at an intracellular locus to increase the presynaptic free calcium concentration.
format Text
id pubmed-2595670
institution National Center for Biotechnology Information
language English
publishDate 1978
record_format MEDLINE/PubMed
spelling pubmed-25956702008-12-05 Phenobarbital Increases Spontaneous Transmitter Release at the Frog Neuromuscular Junction Pincus, Jonathan H. Insler, Nancy F. Yale J Biol Med Original Contributions Phenobarbital (1-2 × 10(-4)M) markedly increases the frequency of miniature end-plate potentials at the neuromuscular synapse of the frog. This effect was seen in calcium free media containing EGTA. The drug probably acts presynaptically at an intracellular locus to increase the presynaptic free calcium concentration. 1978 /pmc/articles/PMC2595670/ /pubmed/28609 Text en
spellingShingle Original Contributions
Pincus, Jonathan H.
Insler, Nancy F.
Phenobarbital Increases Spontaneous Transmitter Release at the Frog Neuromuscular Junction
title Phenobarbital Increases Spontaneous Transmitter Release at the Frog Neuromuscular Junction
title_full Phenobarbital Increases Spontaneous Transmitter Release at the Frog Neuromuscular Junction
title_fullStr Phenobarbital Increases Spontaneous Transmitter Release at the Frog Neuromuscular Junction
title_full_unstemmed Phenobarbital Increases Spontaneous Transmitter Release at the Frog Neuromuscular Junction
title_short Phenobarbital Increases Spontaneous Transmitter Release at the Frog Neuromuscular Junction
title_sort phenobarbital increases spontaneous transmitter release at the frog neuromuscular junction
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595670/
https://www.ncbi.nlm.nih.gov/pubmed/28609
work_keys_str_mv AT pincusjonathanh phenobarbitalincreasesspontaneoustransmitterreleaseatthefrogneuromuscularjunction
AT inslernancyf phenobarbitalincreasesspontaneoustransmitterreleaseatthefrogneuromuscularjunction

Ejemplares similares