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The Role of Renal “Work” in Compensatory Kidney Growth

In a series of studies designed to test the role of renal “work” in compensatory kidney growth we examined the relationship between absolute sodium reabsorption—which constitutes the bulk of renal energy expenditure, and growth of the remaining kidney at various intervals after contralateral nephrec...

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Detalles Bibliográficos
Autores principales: Katz, Adrian I., Toback, F. Gary, Lindheimer, M.D.
Formato: Texto
Lenguaje:English
Publicado: 1978
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595748/
https://www.ncbi.nlm.nih.gov/pubmed/366925
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author Katz, Adrian I.
Toback, F. Gary
Lindheimer, M.D.
author_facet Katz, Adrian I.
Toback, F. Gary
Lindheimer, M.D.
author_sort Katz, Adrian I.
collection PubMed
description In a series of studies designed to test the role of renal “work” in compensatory kidney growth we examined the relationship between absolute sodium reabsorption—which constitutes the bulk of renal energy expenditure, and growth of the remaining kidney at various intervals after contralateral nephrectomy. The increase in weight of the remaining kidney preceded the rise in sodium reabsorption and these two processes took place at different rates between 24 hours and 21 days after uninephrectomy. Absolute sodium reabsorption did not change during the first hours after contralateral nephrectomy, at a time when biochemical alterations are known to occur. The rate of [(14)C] choline incorporation into renal phospholipid, an early biochemical indicator of compensatory kidney growth, increased significantly one hour after contralateral nephrectomy but remained unchanged after sham-nephrectomy, regardless of the magnitude or direction of the concomitant change in absolute sodium reabsorption (“kidney work”). These results indicate that renal work expended in the reabsorption of glomerular filtrate is neither the initiating, nor the primary controlling factor, of the compensatory kidney growth that follows unilateral nephrectomy.
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spelling pubmed-25957482008-12-05 The Role of Renal “Work” in Compensatory Kidney Growth Katz, Adrian I. Toback, F. Gary Lindheimer, M.D. Yale J Biol Med Article In a series of studies designed to test the role of renal “work” in compensatory kidney growth we examined the relationship between absolute sodium reabsorption—which constitutes the bulk of renal energy expenditure, and growth of the remaining kidney at various intervals after contralateral nephrectomy. The increase in weight of the remaining kidney preceded the rise in sodium reabsorption and these two processes took place at different rates between 24 hours and 21 days after uninephrectomy. Absolute sodium reabsorption did not change during the first hours after contralateral nephrectomy, at a time when biochemical alterations are known to occur. The rate of [(14)C] choline incorporation into renal phospholipid, an early biochemical indicator of compensatory kidney growth, increased significantly one hour after contralateral nephrectomy but remained unchanged after sham-nephrectomy, regardless of the magnitude or direction of the concomitant change in absolute sodium reabsorption (“kidney work”). These results indicate that renal work expended in the reabsorption of glomerular filtrate is neither the initiating, nor the primary controlling factor, of the compensatory kidney growth that follows unilateral nephrectomy. 1978 /pmc/articles/PMC2595748/ /pubmed/366925 Text en
spellingShingle Article
Katz, Adrian I.
Toback, F. Gary
Lindheimer, M.D.
The Role of Renal “Work” in Compensatory Kidney Growth
title The Role of Renal “Work” in Compensatory Kidney Growth
title_full The Role of Renal “Work” in Compensatory Kidney Growth
title_fullStr The Role of Renal “Work” in Compensatory Kidney Growth
title_full_unstemmed The Role of Renal “Work” in Compensatory Kidney Growth
title_short The Role of Renal “Work” in Compensatory Kidney Growth
title_sort role of renal “work” in compensatory kidney growth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595748/
https://www.ncbi.nlm.nih.gov/pubmed/366925
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