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High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences.
Propranolol blood levels and the effect of these levels on hemodynamic parameters were evaluated in 25 patients with coronary artery disease undergoing cardiac catheterization and coronary angiography. Fifteen patients were receiving high doses of propranolol (320--1920 mg/day) while ten patients we...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Yale Journal of Biology and Medicine
1980
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595884/ https://www.ncbi.nlm.nih.gov/pubmed/6250292 |
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author | Zito, R. A. Cassell, I. Cunningham, M. Gradman, A. H. Ross, A. M. Zaret, B. L. |
author_facet | Zito, R. A. Cassell, I. Cunningham, M. Gradman, A. H. Ross, A. M. Zaret, B. L. |
author_sort | Zito, R. A. |
collection | PubMed |
description | Propranolol blood levels and the effect of these levels on hemodynamic parameters were evaluated in 25 patients with coronary artery disease undergoing cardiac catheterization and coronary angiography. Fifteen patients were receiving high doses of propranolol (320--1920 mg/day) while ten patients were receiving conventional doses (80--240 mg/day). The high dose propranolol group had significantly higher plasma propranolol levels than the conventional dose group (788 +/- 134 SD vs. 43 +/- 7.2 ng/ml SD), and there was a direct linear relationship between propranolol dose and plasma drug levels (r = 0.85, P < 0.001). There were no significant differences between high and conventional dose propranolol groups in terms of all hemodynamic parameters measured, namely ejection fraction, ventricular volume, cardiac index, or peripheral vascular resistance. Despite high drug dosage and blood levels, only mild side effects were seen. |
format | Text |
id | pubmed-2595884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1980 |
publisher | Yale Journal of Biology and Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-25958842008-12-05 High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences. Zito, R. A. Cassell, I. Cunningham, M. Gradman, A. H. Ross, A. M. Zaret, B. L. Yale J Biol Med Research Article Propranolol blood levels and the effect of these levels on hemodynamic parameters were evaluated in 25 patients with coronary artery disease undergoing cardiac catheterization and coronary angiography. Fifteen patients were receiving high doses of propranolol (320--1920 mg/day) while ten patients were receiving conventional doses (80--240 mg/day). The high dose propranolol group had significantly higher plasma propranolol levels than the conventional dose group (788 +/- 134 SD vs. 43 +/- 7.2 ng/ml SD), and there was a direct linear relationship between propranolol dose and plasma drug levels (r = 0.85, P < 0.001). There were no significant differences between high and conventional dose propranolol groups in terms of all hemodynamic parameters measured, namely ejection fraction, ventricular volume, cardiac index, or peripheral vascular resistance. Despite high drug dosage and blood levels, only mild side effects were seen. Yale Journal of Biology and Medicine 1980 /pmc/articles/PMC2595884/ /pubmed/6250292 Text en |
spellingShingle | Research Article Zito, R. A. Cassell, I. Cunningham, M. Gradman, A. H. Ross, A. M. Zaret, B. L. High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences. |
title | High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences. |
title_full | High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences. |
title_fullStr | High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences. |
title_full_unstemmed | High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences. |
title_short | High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences. |
title_sort | high dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595884/ https://www.ncbi.nlm.nih.gov/pubmed/6250292 |
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