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High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences.

Propranolol blood levels and the effect of these levels on hemodynamic parameters were evaluated in 25 patients with coronary artery disease undergoing cardiac catheterization and coronary angiography. Fifteen patients were receiving high doses of propranolol (320--1920 mg/day) while ten patients we...

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Autores principales: Zito, R. A., Cassell, I., Cunningham, M., Gradman, A. H., Ross, A. M., Zaret, B. L.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1980
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595884/
https://www.ncbi.nlm.nih.gov/pubmed/6250292
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author Zito, R. A.
Cassell, I.
Cunningham, M.
Gradman, A. H.
Ross, A. M.
Zaret, B. L.
author_facet Zito, R. A.
Cassell, I.
Cunningham, M.
Gradman, A. H.
Ross, A. M.
Zaret, B. L.
author_sort Zito, R. A.
collection PubMed
description Propranolol blood levels and the effect of these levels on hemodynamic parameters were evaluated in 25 patients with coronary artery disease undergoing cardiac catheterization and coronary angiography. Fifteen patients were receiving high doses of propranolol (320--1920 mg/day) while ten patients were receiving conventional doses (80--240 mg/day). The high dose propranolol group had significantly higher plasma propranolol levels than the conventional dose group (788 +/- 134 SD vs. 43 +/- 7.2 ng/ml SD), and there was a direct linear relationship between propranolol dose and plasma drug levels (r = 0.85, P < 0.001). There were no significant differences between high and conventional dose propranolol groups in terms of all hemodynamic parameters measured, namely ejection fraction, ventricular volume, cardiac index, or peripheral vascular resistance. Despite high drug dosage and blood levels, only mild side effects were seen.
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spelling pubmed-25958842008-12-05 High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences. Zito, R. A. Cassell, I. Cunningham, M. Gradman, A. H. Ross, A. M. Zaret, B. L. Yale J Biol Med Research Article Propranolol blood levels and the effect of these levels on hemodynamic parameters were evaluated in 25 patients with coronary artery disease undergoing cardiac catheterization and coronary angiography. Fifteen patients were receiving high doses of propranolol (320--1920 mg/day) while ten patients were receiving conventional doses (80--240 mg/day). The high dose propranolol group had significantly higher plasma propranolol levels than the conventional dose group (788 +/- 134 SD vs. 43 +/- 7.2 ng/ml SD), and there was a direct linear relationship between propranolol dose and plasma drug levels (r = 0.85, P < 0.001). There were no significant differences between high and conventional dose propranolol groups in terms of all hemodynamic parameters measured, namely ejection fraction, ventricular volume, cardiac index, or peripheral vascular resistance. Despite high drug dosage and blood levels, only mild side effects were seen. Yale Journal of Biology and Medicine 1980 /pmc/articles/PMC2595884/ /pubmed/6250292 Text en
spellingShingle Research Article
Zito, R. A.
Cassell, I.
Cunningham, M.
Gradman, A. H.
Ross, A. M.
Zaret, B. L.
High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences.
title High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences.
title_full High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences.
title_fullStr High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences.
title_full_unstemmed High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences.
title_short High dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences.
title_sort high dose propranolol in the treatment of angina pectoris: relationship of dose to blood levels and hemodynamic consequences.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595884/
https://www.ncbi.nlm.nih.gov/pubmed/6250292
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