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Initiation and promotion in cancer formation: the importance of studies on intercellular communication.

Three major theories of cancer--somatic mutation, virus causation, and faulty differentiation--are proposed to involve alterations in DNA structure. Each results finally in terms of failures in the normal intercellular communication that involves feedback between differentiated cells acting on less...

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Detalles Bibliográficos
Autor principal: Potter, V. R.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1980
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595915/
https://www.ncbi.nlm.nih.gov/pubmed/7013284
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author Potter, V. R.
author_facet Potter, V. R.
author_sort Potter, V. R.
collection PubMed
description Three major theories of cancer--somatic mutation, virus causation, and faulty differentiation--are proposed to involve alterations in DNA structure. Each results finally in terms of failures in the normal intercellular communication that involves feedback between differentiated cells acting on less differentiated cells still capable of proliferation. The historical background of the latter idea is traced to Osgood, Weiss and Kavanau, and to Iversen. The historical background of concepts of initiation and promotion are traced to Berenblum and Mottram and the Boutwell concept of promotion as gene activation is cited. It is proposed that gene activation by promoters is a valid concept and that it results from the blocking of the normal intercellular communication postulated by Osgood and others. The problem of explaining the low probability of cancer following initiators or promoters acting alone is cited as a problem in basic science. A hypothesis to solve the problem is proposed: Cancer results from two of more relevant mutations: promoters enhance proliferation of cells with one relevant mutation, thereby increasing the probability of obtaining a cell with two relevant mutations. A new scheme of five stages of hepatocarcinogenesis is proposed in terms of the hypothesis and available data.
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spelling pubmed-25959152008-12-05 Initiation and promotion in cancer formation: the importance of studies on intercellular communication. Potter, V. R. Yale J Biol Med Research Article Three major theories of cancer--somatic mutation, virus causation, and faulty differentiation--are proposed to involve alterations in DNA structure. Each results finally in terms of failures in the normal intercellular communication that involves feedback between differentiated cells acting on less differentiated cells still capable of proliferation. The historical background of the latter idea is traced to Osgood, Weiss and Kavanau, and to Iversen. The historical background of concepts of initiation and promotion are traced to Berenblum and Mottram and the Boutwell concept of promotion as gene activation is cited. It is proposed that gene activation by promoters is a valid concept and that it results from the blocking of the normal intercellular communication postulated by Osgood and others. The problem of explaining the low probability of cancer following initiators or promoters acting alone is cited as a problem in basic science. A hypothesis to solve the problem is proposed: Cancer results from two of more relevant mutations: promoters enhance proliferation of cells with one relevant mutation, thereby increasing the probability of obtaining a cell with two relevant mutations. A new scheme of five stages of hepatocarcinogenesis is proposed in terms of the hypothesis and available data. Yale Journal of Biology and Medicine 1980 /pmc/articles/PMC2595915/ /pubmed/7013284 Text en
spellingShingle Research Article
Potter, V. R.
Initiation and promotion in cancer formation: the importance of studies on intercellular communication.
title Initiation and promotion in cancer formation: the importance of studies on intercellular communication.
title_full Initiation and promotion in cancer formation: the importance of studies on intercellular communication.
title_fullStr Initiation and promotion in cancer formation: the importance of studies on intercellular communication.
title_full_unstemmed Initiation and promotion in cancer formation: the importance of studies on intercellular communication.
title_short Initiation and promotion in cancer formation: the importance of studies on intercellular communication.
title_sort initiation and promotion in cancer formation: the importance of studies on intercellular communication.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2595915/
https://www.ncbi.nlm.nih.gov/pubmed/7013284
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