Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

BACKGROUND: The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are therefore viewed as attractive drug candidates for the targeted therapy of this mali...

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Detalles Bibliográficos
Autores principales: Voisin, Laure, Julien, Catherine, Duhamel, Stéphanie, Gopalbhai, Kailesh, Claveau, Isabelle, Saba-El-Leil, Marc K, Rodrigue-Gervais, Ian Gaël, Gaboury, Louis, Lamarre, Daniel, Basik, Mark, Meloche, Sylvain
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596176/
https://www.ncbi.nlm.nih.gov/pubmed/19014680
http://dx.doi.org/10.1186/1471-2407-8-337

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