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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection by recognizing microbial nucleic acids1, 2; however, these responses come at the cost of potential autoimmunity due to inappropriate recognition of self nucleic acid3. The localization of TLR9 and TLR7 to intra...

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Detalles Bibliográficos
Autores principales:	Ewald, Sarah E., Lee, Bettina L., Lau, Laura, Wickliffe, Katherine E., Shi, Guo-Ping, Chapman, Harold A., Barton, Gregory M.
Formato:	Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596276/ https://www.ncbi.nlm.nih.gov/pubmed/18820679 http://dx.doi.org/10.1038/nature07405

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