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Botulinum Neurotoxin Devoid of Receptor Binding Domain Translocates Active Protease

Clostridium botulinum neurotoxin (BoNT) causes flaccid paralysis by disabling synaptic exocytosis. Intoxication requires the tri-modular protein to undergo conformational changes in response to pH and redox gradients across endosomes, leading to the formation of a protein-conducting channel. The ∼50...

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Detalles Bibliográficos
Autores principales:	Fischer, Audrey, Mushrush, Darren J., Lacy, D. Borden, Montal, Mauricio
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596314/ https://www.ncbi.nlm.nih.gov/pubmed/19096517 http://dx.doi.org/10.1371/journal.ppat.1000245

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