Analysis of Germline GLI1 Variation Implicates Hedgehog Signalling in the Regulation of Intestinal Inflammatory Pathways

BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) are polygenic chronic inflammatory bowel diseases (IBD) of high prevalence that are associated with considerable morbidity. The hedgehog (HH) signalling pathway, which includes the transcription factor glioma-associated oncogene homol...

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Detalles Bibliográficos
Autores principales: Lees, Charlie W, Zacharias, William J, Tremelling, Mark, Noble, Colin L, Nimmo, Elaine R, Tenesa, Albert, Cornelius, Jennine, Torkvist, Leif, Kao, John, Farrington, Susan, Drummond, Hazel E, Ho, Gwo-Tzer, Arnott, Ian D. R, Appelman, Henry D, Diehl, Lauri, Campbell, Harry, Dunlop, Malcolm G, Parkes, Miles, Howie, Sarah E. M, Gumucio, Deborah L, Satsangi, Jack
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596854/
https://www.ncbi.nlm.nih.gov/pubmed/19071955
http://dx.doi.org/10.1371/journal.pmed.0050239

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