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Analysis of STAT1 Activation by Six FGFR3 Mutants Associated with Skeletal Dysplasia Undermines Dominant Role of STAT1 in FGFR3 Signaling in Cartilage

Activating mutations in FGFR3 tyrosine kinase cause several forms of human skeletal dysplasia. Although the mechanisms of FGFR3 action in cartilage are not completely understood, it is believed that the STAT1 transcription factor plays a central role in pathogenic FGFR3 signaling. Here, we analyzed...

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Detalles Bibliográficos
Autores principales: Krejci, Pavel, Salazar, Lisa, Kashiwada, Tamara A., Chlebova, Katarina, Salasova, Alena, Thompson, Leslie Michels, Bryja, Vitezslav, Kozubik, Alois, Wilcox, William R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597732/
https://www.ncbi.nlm.nih.gov/pubmed/19088846
http://dx.doi.org/10.1371/journal.pone.0003961

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