Pyrvinium Targets the Unfolded Protein Response to Hypoglycemia and Its Anti-Tumor Activity Is Enhanced by Combination Therapy

We identified pyrvinium pamoate, an old anthelminthic medicine, which preferentially inhibits anchorage-independent growth of cancer cells over anchorage-dependent growth (∼10 fold). It was also reported by others to have anti-tumor activity in vivo and selective toxicity against cancer cells under...

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Detalles Bibliográficos
Autores principales: Yu, De-Hua, Macdonald, James, Liu, Guohong, Lee, Amy S., Ly, Mimi, Davis, Timothy, Ke, Ning, Zhou, Demin, Wong-Staal, Flossie, Li, Qi-Xiang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597738/
https://www.ncbi.nlm.nih.gov/pubmed/19079611
http://dx.doi.org/10.1371/journal.pone.0003951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597738/
https://www.ncbi.nlm.nih.gov/pubmed/19079611
http://dx.doi.org/10.1371/journal.pone.0003951

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