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Cytoplasmic CUG RNA Foci Are Insufficient to Elicit Key DM1 Features
The genetic basis of myotonic dystrophy type I (DM1) is the expansion of a CTG tract located in the 3′ untranslated region of DMPK. Expression of mutant RNAs encoding expanded CUG repeats plays a central role in the development of cardiac disease in DM1. Expanded CUG tracts form both nuclear and cyt...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597774/ https://www.ncbi.nlm.nih.gov/pubmed/19092997 http://dx.doi.org/10.1371/journal.pone.0003968 |