Respiratory viral diseases: access to RNA interference therapy

This review summarizes recent experimental achievements in the area of the development of new RNA interference (RNAi) therapeutics for the treatment of viral respiratory diseases. Delivery of short interfering RNA (siRNA) to their intended target tissue remains the biggest problem for most therapeut...

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Detalles Bibliográficos
Autores principales: Bitko, Vira, Barik, Sailen
Formato: Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597863/
https://www.ncbi.nlm.nih.gov/pubmed/19081824
http://dx.doi.org/10.1016/j.ddstr.2008.01.001
Descripción
Sumario:This review summarizes recent experimental achievements in the area of the development of new RNA interference (RNAi) therapeutics for the treatment of viral respiratory diseases. Delivery of short interfering RNA (siRNA) to their intended target tissue remains the biggest problem for most therapeutic applications of these compounds. Appropriate formulations and chemical modifications for improved stability will boost the probability of utilization of RNAi drugs in the clinical applications.

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