Response to diazepam in children with malaria induced seizures

Malaria infection reduces the binding capacity of benzodiazepine receptors in mice. We studied the efficacy of diazepam terminating seizures in children with falciparum malaria. Diazepam stopped seizures in fewer patients with malaria parasitaemia (χ(2) = 3.93, P = 0.047) and those with clinical dia...

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Detalles Bibliográficos
Autores principales: Ikumi, M.L., Muchohi, S.N., Ohuma, E.O., Kokwaro, G.O., Newton, C.R.J.C.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2599866/
https://www.ncbi.nlm.nih.gov/pubmed/18804958
http://dx.doi.org/10.1016/j.eplepsyres.2008.08.002
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author Ikumi, M.L.
Muchohi, S.N.
Ohuma, E.O.
Kokwaro, G.O.
Newton, C.R.J.C.
author_facet Ikumi, M.L.
Muchohi, S.N.
Ohuma, E.O.
Kokwaro, G.O.
Newton, C.R.J.C.
author_sort Ikumi, M.L.
collection PubMed
description Malaria infection reduces the binding capacity of benzodiazepine receptors in mice. We studied the efficacy of diazepam terminating seizures in children with falciparum malaria. Diazepam stopped seizures in fewer patients with malaria parasitaemia (χ(2) = 3.93, P = 0.047) and those with clinical diagnosis of malaria (χ(2) = 9.84, P = 0.002) compared to those without. However malaria was not identified as an independent risk factor for diazepam's failure to stop seizures in children.
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spelling pubmed-25998662008-12-16 Response to diazepam in children with malaria induced seizures Ikumi, M.L. Muchohi, S.N. Ohuma, E.O. Kokwaro, G.O. Newton, C.R.J.C. Epilepsy Res Short Communication Malaria infection reduces the binding capacity of benzodiazepine receptors in mice. We studied the efficacy of diazepam terminating seizures in children with falciparum malaria. Diazepam stopped seizures in fewer patients with malaria parasitaemia (χ(2) = 3.93, P = 0.047) and those with clinical diagnosis of malaria (χ(2) = 9.84, P = 0.002) compared to those without. However malaria was not identified as an independent risk factor for diazepam's failure to stop seizures in children. Elsevier Science Publishers 2008-12 /pmc/articles/PMC2599866/ /pubmed/18804958 http://dx.doi.org/10.1016/j.eplepsyres.2008.08.002 Text en © 2008 Elsevier B.V. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Short Communication
Ikumi, M.L.
Muchohi, S.N.
Ohuma, E.O.
Kokwaro, G.O.
Newton, C.R.J.C.
Response to diazepam in children with malaria induced seizures
title Response to diazepam in children with malaria induced seizures
title_full Response to diazepam in children with malaria induced seizures
title_fullStr Response to diazepam in children with malaria induced seizures
title_full_unstemmed Response to diazepam in children with malaria induced seizures
title_short Response to diazepam in children with malaria induced seizures
title_sort response to diazepam in children with malaria induced seizures
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2599866/
https://www.ncbi.nlm.nih.gov/pubmed/18804958
http://dx.doi.org/10.1016/j.eplepsyres.2008.08.002
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AT ohumaeo responsetodiazepaminchildrenwithmalariainducedseizures
AT kokwarogo responsetodiazepaminchildrenwithmalariainducedseizures
AT newtoncrjc responsetodiazepaminchildrenwithmalariainducedseizures

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