Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in Environmental Aeromonas spp.

We searched for plasmid-mediated quinolone resistance determinants of the Qnr type in several water samples collected at diverse locations from the Seine River (Paris, France). The qnrS2 genes were identified from Aeromonas punctata subsp. punctata and A. media. The qnrS2 gene was located on IncU-ty...

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Autores principales: Cattoir, Vincent, Poirel, Laurent, Aubert, Camille, Soussy, Claude-James, Nordmann, Patrice
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600179/
https://www.ncbi.nlm.nih.gov/pubmed/18258115
http://dx.doi.org/10.3201/eid1402.070677
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author Cattoir, Vincent
Poirel, Laurent
Aubert, Camille
Soussy, Claude-James
Nordmann, Patrice
author_facet Cattoir, Vincent
Poirel, Laurent
Aubert, Camille
Soussy, Claude-James
Nordmann, Patrice
author_sort Cattoir, Vincent
collection PubMed
description We searched for plasmid-mediated quinolone resistance determinants of the Qnr type in several water samples collected at diverse locations from the Seine River (Paris, France). The qnrS2 genes were identified from Aeromonas punctata subsp. punctata and A. media. The qnrS2 gene was located on IncU-type plasmids in both isolates, which resulted in increased MIC values of quinolones and fluoroquinolones, once they were transferred into Escherichia coli. The qnrS2 gene identified in A. punctata was part of novel genetic structure corresponding to a mobile insertion cassette element. This identification of plasmid-mediated qnr genes outside Enterobacteriaceae underlines a possible diffusion of those resistance determinants within gram-negative rods.
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spelling pubmed-26001792009-01-13 Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in Environmental Aeromonas spp. Cattoir, Vincent Poirel, Laurent Aubert, Camille Soussy, Claude-James Nordmann, Patrice Emerg Infect Dis Research We searched for plasmid-mediated quinolone resistance determinants of the Qnr type in several water samples collected at diverse locations from the Seine River (Paris, France). The qnrS2 genes were identified from Aeromonas punctata subsp. punctata and A. media. The qnrS2 gene was located on IncU-type plasmids in both isolates, which resulted in increased MIC values of quinolones and fluoroquinolones, once they were transferred into Escherichia coli. The qnrS2 gene identified in A. punctata was part of novel genetic structure corresponding to a mobile insertion cassette element. This identification of plasmid-mediated qnr genes outside Enterobacteriaceae underlines a possible diffusion of those resistance determinants within gram-negative rods. Centers for Disease Control and Prevention 2008-02 /pmc/articles/PMC2600179/ /pubmed/18258115 http://dx.doi.org/10.3201/eid1402.070677 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Cattoir, Vincent
Poirel, Laurent
Aubert, Camille
Soussy, Claude-James
Nordmann, Patrice
Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in Environmental Aeromonas spp.
title Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in Environmental Aeromonas spp.
title_full Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in Environmental Aeromonas spp.
title_fullStr Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in Environmental Aeromonas spp.
title_full_unstemmed Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in Environmental Aeromonas spp.
title_short Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in Environmental Aeromonas spp.
title_sort unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental aeromonas spp.
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600179/
https://www.ncbi.nlm.nih.gov/pubmed/18258115
http://dx.doi.org/10.3201/eid1402.070677
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