Cargando…
Diagnosis of Cystic Echinococcosis, Central Peruvian Highlands
We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathio...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600205/ https://www.ncbi.nlm.nih.gov/pubmed/18258119 http://dx.doi.org/10.3201/eid1402.061101 |
_version_ | 1782162132694990848 |
---|---|
author | Gavidia, Cesar M. Gonzalez, Armando E. Zhang, Wenbao McManus, Donald P. Lopera, Luis Ninaquispe, Berenice Garcia, Hector H. Rodríguez, Silvia Verastegui, Manuela Calderon, Carmen Pan, William K.Y. Gilman, Robert H. |
author_facet | Gavidia, Cesar M. Gonzalez, Armando E. Zhang, Wenbao McManus, Donald P. Lopera, Luis Ninaquispe, Berenice Garcia, Hector H. Rodríguez, Silvia Verastegui, Manuela Calderon, Carmen Pan, William K.Y. Gilman, Robert H. |
author_sort | Gavidia, Cesar M. |
collection | PubMed |
description | We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field. |
format | Text |
id | pubmed-2600205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-26002052009-01-13 Diagnosis of Cystic Echinococcosis, Central Peruvian Highlands Gavidia, Cesar M. Gonzalez, Armando E. Zhang, Wenbao McManus, Donald P. Lopera, Luis Ninaquispe, Berenice Garcia, Hector H. Rodríguez, Silvia Verastegui, Manuela Calderon, Carmen Pan, William K.Y. Gilman, Robert H. Emerg Infect Dis Research We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field. Centers for Disease Control and Prevention 2008-02 /pmc/articles/PMC2600205/ /pubmed/18258119 http://dx.doi.org/10.3201/eid1402.061101 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Gavidia, Cesar M. Gonzalez, Armando E. Zhang, Wenbao McManus, Donald P. Lopera, Luis Ninaquispe, Berenice Garcia, Hector H. Rodríguez, Silvia Verastegui, Manuela Calderon, Carmen Pan, William K.Y. Gilman, Robert H. Diagnosis of Cystic Echinococcosis, Central Peruvian Highlands |
title | Diagnosis of Cystic Echinococcosis, Central Peruvian Highlands |
title_full | Diagnosis of Cystic Echinococcosis, Central Peruvian Highlands |
title_fullStr | Diagnosis of Cystic Echinococcosis, Central Peruvian Highlands |
title_full_unstemmed | Diagnosis of Cystic Echinococcosis, Central Peruvian Highlands |
title_short | Diagnosis of Cystic Echinococcosis, Central Peruvian Highlands |
title_sort | diagnosis of cystic echinococcosis, central peruvian highlands |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600205/ https://www.ncbi.nlm.nih.gov/pubmed/18258119 http://dx.doi.org/10.3201/eid1402.061101 |
work_keys_str_mv | AT gavidiacesarm diagnosisofcysticechinococcosiscentralperuvianhighlands AT gonzalezarmandoe diagnosisofcysticechinococcosiscentralperuvianhighlands AT zhangwenbao diagnosisofcysticechinococcosiscentralperuvianhighlands AT mcmanusdonaldp diagnosisofcysticechinococcosiscentralperuvianhighlands AT loperaluis diagnosisofcysticechinococcosiscentralperuvianhighlands AT ninaquispeberenice diagnosisofcysticechinococcosiscentralperuvianhighlands AT garciahectorh diagnosisofcysticechinococcosiscentralperuvianhighlands AT rodriguezsilvia diagnosisofcysticechinococcosiscentralperuvianhighlands AT verasteguimanuela diagnosisofcysticechinococcosiscentralperuvianhighlands AT calderoncarmen diagnosisofcysticechinococcosiscentralperuvianhighlands AT panwilliamky diagnosisofcysticechinococcosiscentralperuvianhighlands AT gilmanroberth diagnosisofcysticechinococcosiscentralperuvianhighlands |