Macrolide-Resistant Shigella sonnei

Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2′-phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit...

Descripción completa

Detalles Bibliográficos
Autores principales: Boumghar-Bourtchai, Leyla, Mariani-Kurkdjian, Patricia, Bingen, Edouard, Filliol, Ingrid, Dhalluin, Anne, Ifrane, Shadia Ait, Weill, François-Xavier, Leclercq, Roland
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2008
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600399/
https://www.ncbi.nlm.nih.gov/pubmed/18680661
http://dx.doi.org/10.3201/eid1408.080147
Descripción
Sumario:Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2′-phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit usefulness of azithromycin for treatment of shigellosis.

Ejemplares similares