Cargando…

Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing

Prism adaptation to rightward optical shifts during visually guided pointing is considered a promising intervention in right-hemisphere stroke patients with left spatial neglect. Conventionally, prism adaptation is assessed via aftereffects, on subjective straight ahead (SSA) pointing with eyes clos...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarri, Margarita, Greenwood, Richard, Kalra, Lalit, Papps, Ben, Husain, Masud, Driver, Jon
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600424/
https://www.ncbi.nlm.nih.gov/pubmed/18083203
http://dx.doi.org/10.1016/j.neuropsychologia.2007.11.005
_version_ 1782162181231476736
author Sarri, Margarita
Greenwood, Richard
Kalra, Lalit
Papps, Ben
Husain, Masud
Driver, Jon
author_facet Sarri, Margarita
Greenwood, Richard
Kalra, Lalit
Papps, Ben
Husain, Masud
Driver, Jon
author_sort Sarri, Margarita
collection PubMed
description Prism adaptation to rightward optical shifts during visually guided pointing is considered a promising intervention in right-hemisphere stroke patients with left spatial neglect. Conventionally, prism adaptation is assessed via aftereffects, on subjective straight ahead (SSA) pointing with eyes closed; or by visual open-loop pointing (VOL), i.e. pointing to a visual target without seeing the hand. Previous data suggest indirectly that prism aftereffects in neglect patients may be larger (pathologically so) when assessed by SSA than by VOL. But these measures have never been directly compared within the same patients after identical prism exposure. Accordingly we implemented both measures here within the same group of 13 neglect patients and 13 controls. Prism aftereffects were much larger for SSA than VOL in neglect patients, falling outside the normative range only for SSA. This may arise because the SSA task can itself involve aspects of neglect that may be ameliorated by the prism intervention, hence showing abnormal changes after prisms. The extent of SSA change after prisms varied between patients, and correlated with improvements on a standard cancellation measure for neglect. The lesions of patients who did versus did not show neglect improvement immediately after prisms provide an initial indication that lack of improvement may potentially relate to cortical damage in right intraparietal sulcus and white matter damage in inferior parietal lobe and middle frontal gyrus. Future studies of possible rehabilitative impact from prisms upon neglect may need to consider carefully how to measure prism adaptation per se, separately from any impact of such adaptation upon manifestations of neglect.
format Text
id pubmed-2600424
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Pergamon Press
record_format MEDLINE/PubMed
spelling pubmed-26004242008-12-10 Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing Sarri, Margarita Greenwood, Richard Kalra, Lalit Papps, Ben Husain, Masud Driver, Jon Neuropsychologia Article Prism adaptation to rightward optical shifts during visually guided pointing is considered a promising intervention in right-hemisphere stroke patients with left spatial neglect. Conventionally, prism adaptation is assessed via aftereffects, on subjective straight ahead (SSA) pointing with eyes closed; or by visual open-loop pointing (VOL), i.e. pointing to a visual target without seeing the hand. Previous data suggest indirectly that prism aftereffects in neglect patients may be larger (pathologically so) when assessed by SSA than by VOL. But these measures have never been directly compared within the same patients after identical prism exposure. Accordingly we implemented both measures here within the same group of 13 neglect patients and 13 controls. Prism aftereffects were much larger for SSA than VOL in neglect patients, falling outside the normative range only for SSA. This may arise because the SSA task can itself involve aspects of neglect that may be ameliorated by the prism intervention, hence showing abnormal changes after prisms. The extent of SSA change after prisms varied between patients, and correlated with improvements on a standard cancellation measure for neglect. The lesions of patients who did versus did not show neglect improvement immediately after prisms provide an initial indication that lack of improvement may potentially relate to cortical damage in right intraparietal sulcus and white matter damage in inferior parietal lobe and middle frontal gyrus. Future studies of possible rehabilitative impact from prisms upon neglect may need to consider carefully how to measure prism adaptation per se, separately from any impact of such adaptation upon manifestations of neglect. Pergamon Press 2008 /pmc/articles/PMC2600424/ /pubmed/18083203 http://dx.doi.org/10.1016/j.neuropsychologia.2007.11.005 Text en © 2008 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Sarri, Margarita
Greenwood, Richard
Kalra, Lalit
Papps, Ben
Husain, Masud
Driver, Jon
Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing
title Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing
title_full Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing
title_fullStr Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing
title_full_unstemmed Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing
title_short Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing
title_sort prism adaptation aftereffects in stroke patients with spatial neglect: pathological effects on subjective straight ahead but not visual open-loop pointing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600424/
https://www.ncbi.nlm.nih.gov/pubmed/18083203
http://dx.doi.org/10.1016/j.neuropsychologia.2007.11.005
work_keys_str_mv AT sarrimargarita prismadaptationaftereffectsinstrokepatientswithspatialneglectpathologicaleffectsonsubjectivestraightaheadbutnotvisualopenlooppointing
AT greenwoodrichard prismadaptationaftereffectsinstrokepatientswithspatialneglectpathologicaleffectsonsubjectivestraightaheadbutnotvisualopenlooppointing
AT kalralalit prismadaptationaftereffectsinstrokepatientswithspatialneglectpathologicaleffectsonsubjectivestraightaheadbutnotvisualopenlooppointing
AT pappsben prismadaptationaftereffectsinstrokepatientswithspatialneglectpathologicaleffectsonsubjectivestraightaheadbutnotvisualopenlooppointing
AT husainmasud prismadaptationaftereffectsinstrokepatientswithspatialneglectpathologicaleffectsonsubjectivestraightaheadbutnotvisualopenlooppointing
AT driverjon prismadaptationaftereffectsinstrokepatientswithspatialneglectpathologicaleffectsonsubjectivestraightaheadbutnotvisualopenlooppointing