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VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse

The signalling lipid PI(3,5)P(2) is generated on endosomes and regulates retrograde traffic to the trans-Golgi network. Physiological signals regulate rapid, transient changes in PI(3,5)P(2) levels. Mutations that lower PI(3,5)P(2) cause neurodegeneration in human patients and mice. The function of...

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Detalles Bibliográficos
Autores principales:	Jin, Natsuko, Chow, Clement Y, Liu, Li, Zolov, Sergey N, Bronson, Roderick, Davisson, Muriel, Petersen, Jason L, Zhang, Yanling, Park, Sujin, Duex, Jason E, Goldowitz, Daniel, Meisler, Miriam H, Weisman, Lois S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600653/ https://www.ncbi.nlm.nih.gov/pubmed/19037259 http://dx.doi.org/10.1038/emboj.2008.248

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