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Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study
In this cross-sectional population-based study we determine human papillomavirus (HPV) prevalence in South Wales to provide comprehensive baseline data for future assessment of the impact of prophylactic HPV vaccination and to help inform future screening strategies. Liquid-based cytology samples fr...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600697/ https://www.ncbi.nlm.nih.gov/pubmed/19034285 http://dx.doi.org/10.1038/sj.bjc.6604748 |
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author | Hibbitts, S Jones, J Powell, N Dallimore, N McRea, J Beer, H Tristram, A Fielder, H Fiander, A N |
author_facet | Hibbitts, S Jones, J Powell, N Dallimore, N McRea, J Beer, H Tristram, A Fielder, H Fiander, A N |
author_sort | Hibbitts, S |
collection | PubMed |
description | In this cross-sectional population-based study we determine human papillomavirus (HPV) prevalence in South Wales to provide comprehensive baseline data for future assessment of the impact of prophylactic HPV vaccination and to help inform future screening strategies. Liquid-based cytology samples from women attending routine cervical screening were collected (n=10 000: mean age 38 years, 93% cytology negative, and 64.8% from the 50% least deprived LSOA according to social deprivation score (SDS)). High-Risk (HR) and Low-Risk HPV screening was performed using HPV PCR-EIA with genotyping of HR positives and data correlated with age, SDS and cytology. Overall HPV prevalence was 13.5% (9.3% age standardised) and the most frequent HR types were HPV 16, 31, 18 and 58. In HR HPV-positive cases 42.4% had a single HR type and they were predominant in women with severe cytological abnormalities. Here, 66% of all HR HPV cases were in women aged 30 years of age or less and SDS had no significant effect on HPV status. HPV prevalence increased significantly with degree of dyskarosis from 7% in cytology negative samples to 80% in samples with severe cytological abnormalities (P-value <0.0001). Overall, 46% of HR HPV cases were positive for the two HR types targeted by the prophylactic vaccines (HPV 16 and HPV 18). The data presented represents the largest type-specific investigation of HPV prevalence in an unselected UK population. |
format | Text |
id | pubmed-2600697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-26006972009-12-03 Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study Hibbitts, S Jones, J Powell, N Dallimore, N McRea, J Beer, H Tristram, A Fielder, H Fiander, A N Br J Cancer Epidemiology In this cross-sectional population-based study we determine human papillomavirus (HPV) prevalence in South Wales to provide comprehensive baseline data for future assessment of the impact of prophylactic HPV vaccination and to help inform future screening strategies. Liquid-based cytology samples from women attending routine cervical screening were collected (n=10 000: mean age 38 years, 93% cytology negative, and 64.8% from the 50% least deprived LSOA according to social deprivation score (SDS)). High-Risk (HR) and Low-Risk HPV screening was performed using HPV PCR-EIA with genotyping of HR positives and data correlated with age, SDS and cytology. Overall HPV prevalence was 13.5% (9.3% age standardised) and the most frequent HR types were HPV 16, 31, 18 and 58. In HR HPV-positive cases 42.4% had a single HR type and they were predominant in women with severe cytological abnormalities. Here, 66% of all HR HPV cases were in women aged 30 years of age or less and SDS had no significant effect on HPV status. HPV prevalence increased significantly with degree of dyskarosis from 7% in cytology negative samples to 80% in samples with severe cytological abnormalities (P-value <0.0001). Overall, 46% of HR HPV cases were positive for the two HR types targeted by the prophylactic vaccines (HPV 16 and HPV 18). The data presented represents the largest type-specific investigation of HPV prevalence in an unselected UK population. Nature Publishing Group 2008-12-02 2008-10-28 /pmc/articles/PMC2600697/ /pubmed/19034285 http://dx.doi.org/10.1038/sj.bjc.6604748 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Hibbitts, S Jones, J Powell, N Dallimore, N McRea, J Beer, H Tristram, A Fielder, H Fiander, A N Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study |
title | Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study |
title_full | Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study |
title_fullStr | Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study |
title_full_unstemmed | Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study |
title_short | Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study |
title_sort | human papillomavirus prevalence in women attending routine cervical screening in south wales, uk: a cross-sectional study |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600697/ https://www.ncbi.nlm.nih.gov/pubmed/19034285 http://dx.doi.org/10.1038/sj.bjc.6604748 |
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