Epstein–Barr virus renders the infected natural killer cell line, NKL resistant to doxorubicin-induced apoptosis

We established two Epstein–Barr virus (EBV)-infected NKL sublines, which acquired stress resistant phenotype against DNA damage and starvation compared with EBV-negative NKL. EBV-rendered doxorubicin resistance at least partially through NF-κB activation and the resultant sustenance of antiapoptotic...

Descripción completa

Detalles Bibliográficos
Autores principales: Isobe, Y, Sugimoto, K, Matsuura, I, Takada, K, Oshimi, K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600699/
https://www.ncbi.nlm.nih.gov/pubmed/18985034
http://dx.doi.org/10.1038/sj.bjc.6604764
Descripción
Sumario:We established two Epstein–Barr virus (EBV)-infected NKL sublines, which acquired stress resistant phenotype against DNA damage and starvation compared with EBV-negative NKL. EBV-rendered doxorubicin resistance at least partially through NF-κB activation and the resultant sustenance of antiapoptotic proteins including Bcl-X(L) and FLIP(L/S).

Ejemplares similares