Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin' aPart

The GTPase Cdc42 was among the original genes identified with roles in cell polarity, and interest in its cellular roles from yeast to humans remains high. Cdc42 is a well-known regulator of the actin cytoskeleton, but also plays important roles in vesicular trafficking. In this issue, Harris and Te...

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Detalles Bibliográficos
Autores principales: Duncan, Mara C., Peifer, Mark
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600754/
https://www.ncbi.nlm.nih.gov/pubmed/19064672
http://dx.doi.org/10.1083/jcb.200811057
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author Duncan, Mara C.
Peifer, Mark
author_facet Duncan, Mara C.
Peifer, Mark
author_sort Duncan, Mara C.
collection PubMed
description The GTPase Cdc42 was among the original genes identified with roles in cell polarity, and interest in its cellular roles from yeast to humans remains high. Cdc42 is a well-known regulator of the actin cytoskeleton, but also plays important roles in vesicular trafficking. In this issue, Harris and Tepass (Harris, K.P, and U. Tepass. 2008. J. Cell. Biol. 183:1129–1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins.
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spelling pubmed-26007542009-06-15 Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin' aPart Duncan, Mara C. Peifer, Mark J Cell Biol Reviews The GTPase Cdc42 was among the original genes identified with roles in cell polarity, and interest in its cellular roles from yeast to humans remains high. Cdc42 is a well-known regulator of the actin cytoskeleton, but also plays important roles in vesicular trafficking. In this issue, Harris and Tepass (Harris, K.P, and U. Tepass. 2008. J. Cell. Biol. 183:1129–1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins. The Rockefeller University Press 2008-12-15 /pmc/articles/PMC2600754/ /pubmed/19064672 http://dx.doi.org/10.1083/jcb.200811057 Text en © 2008 Duncan and Peifer This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Duncan, Mara C.
Peifer, Mark
Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin' aPart
title Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin' aPart
title_full Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin' aPart
title_fullStr Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin' aPart
title_full_unstemmed Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin' aPart
title_short Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin' aPart
title_sort regulating polarity by directing traffic: cdc42 prevents adherens junctions from crumblin' apart
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600754/
https://www.ncbi.nlm.nih.gov/pubmed/19064672
http://dx.doi.org/10.1083/jcb.200811057
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