Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

BACKGROUND: Mutations in the presenilin (PSEN) genes are associated with early-onset familial Alzheimer's disease (FAD). Biochemical characterizations and comparisons have revealed that many PSEN mutations alter γ-secretase activity to promote accumulation of toxic Aβ42 peptides. In this study,...

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Detalles Bibliográficos
Autores principales: Maarouf, Chera L, Daugs, Ian D, Spina, Salvatore, Vidal, Ruben, Kokjohn, Tyler A, Patton, R Lyle, Kalback, Walter M, Luehrs, Dean C, Walker, Douglas G, Castaño, Eduardo M, Beach, Thomas G, Ghetti, Bernardino, Roher, Alex E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600784/
https://www.ncbi.nlm.nih.gov/pubmed/19021905
http://dx.doi.org/10.1186/1750-1326-3-20

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