An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice

BACKGROUND: Despite its reported pro-inflammatory activity, cyclooxygenase (COX)-2 has been proposed to play a protective role in asthma. Accordingly, COX-2 might be down-regulated in the airway cells of asthmatics. This, together with results of experiments to assess the impact of COX-2 blockade in...

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Detalles Bibliográficos
Autores principales: Torres, Rosa, Herrerias, Aida, Serra-Pagès, Mariona, Roca-Ferrer, Jordi, Pujols, Laura, Marco, Alberto, Picado, César, de Mora, Fernando
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600823/
https://www.ncbi.nlm.nih.gov/pubmed/19014484
http://dx.doi.org/10.1186/1465-9921-9-72

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