Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection

Development of vaccines against severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is crucial in the prevention of SARS reemergence. The receptor-binding domain (RBD) of SARS-CoV spike (S) protein is an important target in developing safe and effective SARS vaccines. Our previous study...

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Detalles Bibliográficos
Autores principales: Du, Lanying, Zhao, Guangyu, Lin, Yongping, Chan, Chris, He, Yuxian, Jiang, Shibo, Wu, Changyou, Jin, Dong-Yan, Yuen, Kwok-Yung, Zhou, Yusen, Zheng, Bo-Jian
Formato: Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600875/
https://www.ncbi.nlm.nih.gov/pubmed/18289745
http://dx.doi.org/10.1016/j.vaccine.2008.01.025

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