Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNγ-dependent iNOS expression in the vasculature of healthy mice

Whether leukocytes exert an influence on vascular function in vivo is not known. Here, genetic and pharmacologic approaches show that the absence of neutrophils leads to acute blood pressure dysregulation. Following neutrophil depletion, systolic blood pressure falls significantly over 3 days (88.0...

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Detalles Bibliográficos
Autores principales: Morton, Jonathan, Coles, Barbara, Wright, Kate, Gallimore, Awen, Morrow, Jason D., Terry, Erin S., Anning, Peter B., Morgan, B. Paul, Dioszeghy, Vincent, Kühn, Hartmut, Chaitidis, Pavlos, Hobbs, Adrian J., Jones, Simon A., O'Donnell, Valerie B.
Formato: Texto
Lenguaje:English
Publicado: American Society of Hematology 2008
Materias:
Phagocytes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602588/
https://www.ncbi.nlm.nih.gov/pubmed/18281503
http://dx.doi.org/10.1182/blood-2007-10-117283

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