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Strong Association of a Common Dihydropyrimidine Dehydrogenase Gene Polymorphism with Fluoropyrimidine-Related Toxicity in Cancer Patients

BACKGROUND: Cancer patients carrying mutations in the dihydropyrimidine dehydrogenase gene (DPYD) have a high risk to experience severe drug-adverse effects following chemotherapy with fluoropyrimidine drugs such as 5-fluorouracil (5-FU) or capecitabine. The pretreatment detection of this impairment...

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Detalles Bibliográficos
Autores principales:	Gross, Eva, Busse, Birgit, Riemenschneider, Matthias, Neubauer, Steffi, Seck, Katharina, Klein, Hanns-Georg, Kiechle, Marion, Lordick, Florian, Meindl, Alfons
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602733/ https://www.ncbi.nlm.nih.gov/pubmed/19104657 http://dx.doi.org/10.1371/journal.pone.0004003

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