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The Staphylococcus aureus Protein Sbi Acts as a Complement Inhibitor and Forms a Tripartite Complex with Host Complement Factor H and C3b

The Gram-positive bacterium Staphylococcus aureus, similar to other pathogens, binds human complement regulators Factor H and Factor H related protein 1 (FHR-1) from human serum. Here we identify the secreted protein Sbi (Staphylococcus aureus binder of IgG) as a ligand that interacts with Factor H...

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Detalles Bibliográficos
Autores principales:	Haupt, Katrin, Reuter, Michael, van den Elsen, Jean, Burman, Julia, Hälbich, Steffi, Richter, Julia, Skerka, Christine, Zipfel, Peter F.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602735/ https://www.ncbi.nlm.nih.gov/pubmed/19112495 http://dx.doi.org/10.1371/journal.ppat.1000250

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