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Efficient processing of TFO-directed psoralen DNA interstrand crosslinks by the UvrABC nuclease

Photoreactive psoralens can form interstrand crosslinks (ICLs) in double-stranded DNA. In eubacteria, the endonuclease UvrABC plays a key role in processing psoralen ICLs. Psoralen-modified triplex-forming oligonucleotides (TFOs) can be used to direct ICLs to specific genomic sites. Previous studies...

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Detalles Bibliográficos
Autores principales:	Christensen, Laura A., Wang, Hong, Van Houten, Bennett, Vasquez, Karen M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602775/ https://www.ncbi.nlm.nih.gov/pubmed/18996898 http://dx.doi.org/10.1093/nar/gkn880

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