Phosphorylation Regulates SIRT1 Function

BACKGROUND: SIR2 is an NAD(+)-dependent deacetylase [1]–[3] implicated in the regulation of lifespan in species as diverse as yeast [4], worms [5], and flies [6]. We previously reported that the level of SIRT1, the mammalian homologue of SIR2 [7], [8], is coupled to the level of mitotic activity in...

Descripción completa

Detalles Bibliográficos
Autores principales: Sasaki, Tsutomu, Maier, Bernhard, Koclega, Katarzyna D., Chruszcz, Maksymilian, Gluba, Wendy, Stukenberg, P. Todd, Minor, Wladek, Scrable, Heidi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602979/
https://www.ncbi.nlm.nih.gov/pubmed/19107194
http://dx.doi.org/10.1371/journal.pone.0004020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602979/
https://www.ncbi.nlm.nih.gov/pubmed/19107194
http://dx.doi.org/10.1371/journal.pone.0004020

Ejemplares similares