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Phosphorylation Regulates SIRT1 Function
BACKGROUND: SIR2 is an NAD(+)-dependent deacetylase [1]–[3] implicated in the regulation of lifespan in species as diverse as yeast [4], worms [5], and flies [6]. We previously reported that the level of SIRT1, the mammalian homologue of SIR2 [7], [8], is coupled to the level of mitotic activity in...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602979/ https://www.ncbi.nlm.nih.gov/pubmed/19107194 http://dx.doi.org/10.1371/journal.pone.0004020 |