Hemostasis and ageing

On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is associated with increased plasma levels of many proteins of blood coagulation together with fi...

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Autores principales: Mari, Daniela, Ogliari, Giulia, Castaldi, Davide, Vitale, Giovanni, Bollini, Elisa Mariadele, Lio, Domenico
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602988/
https://www.ncbi.nlm.nih.gov/pubmed/18947391
http://dx.doi.org/10.1186/1742-4933-5-12
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author Mari, Daniela
Ogliari, Giulia
Castaldi, Davide
Vitale, Giovanni
Bollini, Elisa Mariadele
Lio, Domenico
author_facet Mari, Daniela
Ogliari, Giulia
Castaldi, Davide
Vitale, Giovanni
Bollini, Elisa Mariadele
Lio, Domenico
author_sort Mari, Daniela
collection PubMed
description On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is associated with increased plasma levels of many proteins of blood coagulation together with fibrinolysis impairment. This may be of great concern in view of the known association between vascular and thromboembolic diseases and ageing. On the other hand, centenarians are characterized by a state of hypercoagulability and possession of several high-risk alleles and well-known atherothrombotic risk markers but this appears to be compatible with longevity and/or health. Parameters considered risk factors for atherosclerotic vascular diseases in young people may lose their biological significance in advanced age and assume a different role.
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spelling pubmed-26029882008-12-16 Hemostasis and ageing Mari, Daniela Ogliari, Giulia Castaldi, Davide Vitale, Giovanni Bollini, Elisa Mariadele Lio, Domenico Immun Ageing Short Report On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is associated with increased plasma levels of many proteins of blood coagulation together with fibrinolysis impairment. This may be of great concern in view of the known association between vascular and thromboembolic diseases and ageing. On the other hand, centenarians are characterized by a state of hypercoagulability and possession of several high-risk alleles and well-known atherothrombotic risk markers but this appears to be compatible with longevity and/or health. Parameters considered risk factors for atherosclerotic vascular diseases in young people may lose their biological significance in advanced age and assume a different role. BioMed Central 2008-10-23 /pmc/articles/PMC2602988/ /pubmed/18947391 http://dx.doi.org/10.1186/1742-4933-5-12 Text en Copyright © 2008 Mari et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Mari, Daniela
Ogliari, Giulia
Castaldi, Davide
Vitale, Giovanni
Bollini, Elisa Mariadele
Lio, Domenico
Hemostasis and ageing
title Hemostasis and ageing
title_full Hemostasis and ageing
title_fullStr Hemostasis and ageing
title_full_unstemmed Hemostasis and ageing
title_short Hemostasis and ageing
title_sort hemostasis and ageing
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602988/
https://www.ncbi.nlm.nih.gov/pubmed/18947391
http://dx.doi.org/10.1186/1742-4933-5-12
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AT castaldidavide hemostasisandageing
AT vitalegiovanni hemostasisandageing
AT bollinielisamariadele hemostasisandageing
AT liodomenico hemostasisandageing

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