How HTLV-1 may subvert miRNAs for persistence and transformation

Distinct mechanisms are used by viruses to interact with cellular miRNAs. The role of microRNAs in viral replication and persistence ranges from viral-encoded microRNAs to suppressors of RNA interference. Viruses can also exploit cellular miRNAs for influencing cellular metabolism to ensure efficien...

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Detalles Bibliográficos
Autores principales: Bouzar, Amel B, Willems, Luc
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603043/
https://www.ncbi.nlm.nih.gov/pubmed/19014483
http://dx.doi.org/10.1186/1742-4690-5-101
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author Bouzar, Amel B
Willems, Luc
author_facet Bouzar, Amel B
Willems, Luc
author_sort Bouzar, Amel B
collection PubMed
description Distinct mechanisms are used by viruses to interact with cellular miRNAs. The role of microRNAs in viral replication and persistence ranges from viral-encoded microRNAs to suppressors of RNA interference. Viruses can also exploit cellular miRNAs for influencing cellular metabolism to ensure efficient replication or latency. In particular, two recent studies provide examples of how HTLV-1 may co-opt or subvert cellular miRNAs for persistent replication and oncogenic purposes. The pathways modulated by these described miRNAs are critically involved in apoptosis, proliferation and innate immune response.
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spelling pubmed-26030432008-12-16 How HTLV-1 may subvert miRNAs for persistence and transformation Bouzar, Amel B Willems, Luc Retrovirology Commentary Distinct mechanisms are used by viruses to interact with cellular miRNAs. The role of microRNAs in viral replication and persistence ranges from viral-encoded microRNAs to suppressors of RNA interference. Viruses can also exploit cellular miRNAs for influencing cellular metabolism to ensure efficient replication or latency. In particular, two recent studies provide examples of how HTLV-1 may co-opt or subvert cellular miRNAs for persistent replication and oncogenic purposes. The pathways modulated by these described miRNAs are critically involved in apoptosis, proliferation and innate immune response. BioMed Central 2008-11-12 /pmc/articles/PMC2603043/ /pubmed/19014483 http://dx.doi.org/10.1186/1742-4690-5-101 Text en Copyright © 2008 Bouzar and Willems; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Bouzar, Amel B
Willems, Luc
How HTLV-1 may subvert miRNAs for persistence and transformation
title How HTLV-1 may subvert miRNAs for persistence and transformation
title_full How HTLV-1 may subvert miRNAs for persistence and transformation
title_fullStr How HTLV-1 may subvert miRNAs for persistence and transformation
title_full_unstemmed How HTLV-1 may subvert miRNAs for persistence and transformation
title_short How HTLV-1 may subvert miRNAs for persistence and transformation
title_sort how htlv-1 may subvert mirnas for persistence and transformation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603043/
https://www.ncbi.nlm.nih.gov/pubmed/19014483
http://dx.doi.org/10.1186/1742-4690-5-101
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