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Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans

Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis–like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We condu...

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Autores principales: Drexler, Jan Felix, Luna, Luciano Kleber de Souza, Stöcker, Andreas, Almeida, Patrícia Silva, Ribeiro, Tereza Cristina Medrado, Petersen, Nadine, Herzog, Petra, Pedroso, Célia, Huppertz, Hans Iko, Ribeiro, Hugo da Costa, Baumgarte, Sigrid, Drosten, Christian
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603095/
https://www.ncbi.nlm.nih.gov/pubmed/18760006
http://dx.doi.org/10.3201/eid1409.080570
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author Drexler, Jan Felix
Luna, Luciano Kleber de Souza
Stöcker, Andreas
Almeida, Patrícia Silva
Ribeiro, Tereza Cristina Medrado
Petersen, Nadine
Herzog, Petra
Pedroso, Célia
Huppertz, Hans Iko
Ribeiro, Hugo da Costa
Baumgarte, Sigrid
Drosten, Christian
author_facet Drexler, Jan Felix
Luna, Luciano Kleber de Souza
Stöcker, Andreas
Almeida, Patrícia Silva
Ribeiro, Tereza Cristina Medrado
Petersen, Nadine
Herzog, Petra
Pedroso, Célia
Huppertz, Hans Iko
Ribeiro, Hugo da Costa
Baumgarte, Sigrid
Drosten, Christian
author_sort Drexler, Jan Felix
collection PubMed
description Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis–like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We conducted systematic molecular screening for Saffold-like viruses in 844 fecal samples from patients with gastroenteritis from Germany and Brazil, across all age groups. Six cardioviruses were identified in patients <6 years of age. Viral loads were 283,305–5,044,412,175 copies/g of stool. Co-infections occurred in 4 of 6 children. No evidence for outbreak-like epidemic patterns was found. Phylogenetic analysis identified 3 distinct genetic lineages. Viral protein 1 amino acids were 67.9%–77.7% identical and had a distance of at least 39.4% from known cardioviruses. Because closely related strains were found on 2 continents, global distribution in humans is suspected. Saffold-like viruses may be the first human cardiovirus species to be identified.
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spelling pubmed-26030952009-01-13 Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans Drexler, Jan Felix Luna, Luciano Kleber de Souza Stöcker, Andreas Almeida, Patrícia Silva Ribeiro, Tereza Cristina Medrado Petersen, Nadine Herzog, Petra Pedroso, Célia Huppertz, Hans Iko Ribeiro, Hugo da Costa Baumgarte, Sigrid Drosten, Christian Emerg Infect Dis Research Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis–like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We conducted systematic molecular screening for Saffold-like viruses in 844 fecal samples from patients with gastroenteritis from Germany and Brazil, across all age groups. Six cardioviruses were identified in patients <6 years of age. Viral loads were 283,305–5,044,412,175 copies/g of stool. Co-infections occurred in 4 of 6 children. No evidence for outbreak-like epidemic patterns was found. Phylogenetic analysis identified 3 distinct genetic lineages. Viral protein 1 amino acids were 67.9%–77.7% identical and had a distance of at least 39.4% from known cardioviruses. Because closely related strains were found on 2 continents, global distribution in humans is suspected. Saffold-like viruses may be the first human cardiovirus species to be identified. Centers for Disease Control and Prevention 2008-09 /pmc/articles/PMC2603095/ /pubmed/18760006 http://dx.doi.org/10.3201/eid1409.080570 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Drexler, Jan Felix
Luna, Luciano Kleber de Souza
Stöcker, Andreas
Almeida, Patrícia Silva
Ribeiro, Tereza Cristina Medrado
Petersen, Nadine
Herzog, Petra
Pedroso, Célia
Huppertz, Hans Iko
Ribeiro, Hugo da Costa
Baumgarte, Sigrid
Drosten, Christian
Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans
title Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans
title_full Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans
title_fullStr Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans
title_full_unstemmed Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans
title_short Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans
title_sort circulation of 3 lineages of a novel saffold cardiovirus in humans
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603095/
https://www.ncbi.nlm.nih.gov/pubmed/18760006
http://dx.doi.org/10.3201/eid1409.080570
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