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TRAF6 Autoubiquitination-Independent Activation of the NFκB and MAPK Pathways in Response to IL-1 and RANKL

The adapter protein TRAF6 is critical for mediating signal transduction from members of the IL-1R/TLR and TNFR superfamilies. The TRAF6 RING finger domain functions as an ubiquitin E3 ligase capable of generating non-degradative K63-linked ubiquitin chains. It is believed that these chains serve as...

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Detalles Bibliográficos
Autores principales:	Walsh, Matthew C., Kim, Gregory K., Maurizio, Paul L., Molnar, Elizabeth E., Choi, Yongwon
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603309/ https://www.ncbi.nlm.nih.gov/pubmed/19112497 http://dx.doi.org/10.1371/journal.pone.0004064

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