In C. elegans, High Levels of dsRNA Allow RNAi in the Absence of RDE-4

C. elegans Dicer requires an accessory double-stranded RNA binding protein, RDE-4, to enact the first step of RNA interference, the cleavage of dsRNA to produce siRNA. While RDE-4 is typically essential for RNAi, we report that in the presence of high concentrations of trigger dsRNA, rde-4 deficient...

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Detalles Bibliográficos
Autores principales: Habig, Jeffrey W., Aruscavage, P. Joseph, Bass, Brenda L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603325/
https://www.ncbi.nlm.nih.gov/pubmed/19112503
http://dx.doi.org/10.1371/journal.pone.0004052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603325/
https://www.ncbi.nlm.nih.gov/pubmed/19112503
http://dx.doi.org/10.1371/journal.pone.0004052

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