Evolutionary Sequence Modeling for Discovery of Peptide Hormones

There are currently a large number of “orphan” G-protein-coupled receptors (GPCRs) whose endogenous ligands (peptide hormones) are unknown. Identification of these peptide hormones is a difficult and important problem. We describe a computational framework that models spatial structure along the gen...

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Detalles Bibliográficos
Autores principales: Sonmez, Kemal, Zaveri, Naunihal T., Kerman, Ilan A., Burke, Sharon, Neal, Charles R., Xie, Xinmin, Watson, Stanley J., Toll, Lawrence
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603333/
https://www.ncbi.nlm.nih.gov/pubmed/19132080
http://dx.doi.org/10.1371/journal.pcbi.1000258

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