Gamma-Secretase-Dependent and -Independent Effects of Presenilin1 on β-Catenin·Tcf-4 Transcriptional Activity

Presenilin1 (PS1) is a component of the γ-secretase complex mutated in cases of Familial Alzheimer's disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated. Processing of PS1 is inhibited by several mutations detected in...

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Detalles Bibliográficos
Autores principales: Raurell, Imma, Codina, Montserrat, Casagolda, David, del Valle, Beatriz, Baulida, Josep, de Herreros, Antonio García, Duñach, Mireia
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603589/
https://www.ncbi.nlm.nih.gov/pubmed/19114997
http://dx.doi.org/10.1371/journal.pone.0004080

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