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Small molecule activators of the Trk receptors for neuroprotection

The neurotophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's disease. Therapeutic use of neurotrophins t...

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Detalles Bibliográficos
Autores principales: Webster, Nicholas JG, Pirrung, Michael C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604901/
https://www.ncbi.nlm.nih.gov/pubmed/19090982
http://dx.doi.org/10.1186/1471-2202-9-S2-S1
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author Webster, Nicholas JG
Pirrung, Michael C
author_facet Webster, Nicholas JG
Pirrung, Michael C
author_sort Webster, Nicholas JG
collection PubMed
description The neurotophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's disease. Therapeutic use of neurotrophins to prevent this loss is hampered, however, by a number of pharmacological challenges. These include a lack of transport across the blood-brain barrier, rapid degradation in the circulation, and difficulty in production. In this review we discuss the evidence supporting the neurotrophin system's role in preventing neurodegeneration and survey some of the pharmacological strategies being pursued to develop effective therapeutics targeting neurotrophin function.
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spelling pubmed-26049012008-12-18 Small molecule activators of the Trk receptors for neuroprotection Webster, Nicholas JG Pirrung, Michael C BMC Neurosci Review The neurotophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's disease. Therapeutic use of neurotrophins to prevent this loss is hampered, however, by a number of pharmacological challenges. These include a lack of transport across the blood-brain barrier, rapid degradation in the circulation, and difficulty in production. In this review we discuss the evidence supporting the neurotrophin system's role in preventing neurodegeneration and survey some of the pharmacological strategies being pursued to develop effective therapeutics targeting neurotrophin function. BioMed Central 2008-12-03 /pmc/articles/PMC2604901/ /pubmed/19090982 http://dx.doi.org/10.1186/1471-2202-9-S2-S1 Text en Copyright © 2008 Webster and Pirrung; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Webster, Nicholas JG
Pirrung, Michael C
Small molecule activators of the Trk receptors for neuroprotection
title Small molecule activators of the Trk receptors for neuroprotection
title_full Small molecule activators of the Trk receptors for neuroprotection
title_fullStr Small molecule activators of the Trk receptors for neuroprotection
title_full_unstemmed Small molecule activators of the Trk receptors for neuroprotection
title_short Small molecule activators of the Trk receptors for neuroprotection
title_sort small molecule activators of the trk receptors for neuroprotection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604901/
https://www.ncbi.nlm.nih.gov/pubmed/19090982
http://dx.doi.org/10.1186/1471-2202-9-S2-S1
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