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Small molecule activators of the Trk receptors for neuroprotection
The neurotophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's disease. Therapeutic use of neurotrophins t...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604901/ https://www.ncbi.nlm.nih.gov/pubmed/19090982 http://dx.doi.org/10.1186/1471-2202-9-S2-S1 |
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author | Webster, Nicholas JG Pirrung, Michael C |
author_facet | Webster, Nicholas JG Pirrung, Michael C |
author_sort | Webster, Nicholas JG |
collection | PubMed |
description | The neurotophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's disease. Therapeutic use of neurotrophins to prevent this loss is hampered, however, by a number of pharmacological challenges. These include a lack of transport across the blood-brain barrier, rapid degradation in the circulation, and difficulty in production. In this review we discuss the evidence supporting the neurotrophin system's role in preventing neurodegeneration and survey some of the pharmacological strategies being pursued to develop effective therapeutics targeting neurotrophin function. |
format | Text |
id | pubmed-2604901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26049012008-12-18 Small molecule activators of the Trk receptors for neuroprotection Webster, Nicholas JG Pirrung, Michael C BMC Neurosci Review The neurotophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal forebrain are progressively lost in Alzheimer's disease. Therapeutic use of neurotrophins to prevent this loss is hampered, however, by a number of pharmacological challenges. These include a lack of transport across the blood-brain barrier, rapid degradation in the circulation, and difficulty in production. In this review we discuss the evidence supporting the neurotrophin system's role in preventing neurodegeneration and survey some of the pharmacological strategies being pursued to develop effective therapeutics targeting neurotrophin function. BioMed Central 2008-12-03 /pmc/articles/PMC2604901/ /pubmed/19090982 http://dx.doi.org/10.1186/1471-2202-9-S2-S1 Text en Copyright © 2008 Webster and Pirrung; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Webster, Nicholas JG Pirrung, Michael C Small molecule activators of the Trk receptors for neuroprotection |
title | Small molecule activators of the Trk receptors for neuroprotection |
title_full | Small molecule activators of the Trk receptors for neuroprotection |
title_fullStr | Small molecule activators of the Trk receptors for neuroprotection |
title_full_unstemmed | Small molecule activators of the Trk receptors for neuroprotection |
title_short | Small molecule activators of the Trk receptors for neuroprotection |
title_sort | small molecule activators of the trk receptors for neuroprotection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604901/ https://www.ncbi.nlm.nih.gov/pubmed/19090982 http://dx.doi.org/10.1186/1471-2202-9-S2-S1 |
work_keys_str_mv | AT websternicholasjg smallmoleculeactivatorsofthetrkreceptorsforneuroprotection AT pirrungmichaelc smallmoleculeactivatorsofthetrkreceptorsforneuroprotection |