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Coregulation of CD8(+) T cell exhaustion during chronic viral infection by multiple inhibitory receptors
T cell exhaustion often occurs during chronic infections and prevents optimal viral control. The molecular pathways involved in T cell exhaustion, however, remain poorly understood. We demonstrate that exhausted CD8(+) T cells are subject to complex layers of negative regulation due to co-expression...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605166/ https://www.ncbi.nlm.nih.gov/pubmed/19043418 http://dx.doi.org/10.1038/ni.1679 |